Nat Cell Biol: New immune cells found in the breast that can reshape the breast and prevent breast cancer!

May 12, 2020 /
Biovalley BIOON/- Researchers in Melbourne's Breast Cancer have discovered a new type of immune cell that can help maintain the health of breast tissue by regulating an important process in the breast catheter Breast catheters are not only a place for milk and transport, but also the site of most breast cancers using advanced 3D imaging techniques, the team observed how immune cells monitor threats in breast catheters and help maintain tissue health by "eating" dying milk cells that need to be removed after lactation stops the preclinical study, led by researchers Dr Caleb Dawon, Professor Geoff Lindeman and Professor Jane Biolog, and Dr Anne Rio, of the Walter and Eliza Hall Institute of Medicine in Australia, was published recently picture source: Dr Caleb Dawon, Walter and Eliza Hall Intitute maintainbreast tissue health
breast is a dynamic organ that has undergone dramatic remodeling throughout her life These forked catheters form milkproduction "factories" that must be removed once the lactation stops Breast catheters are a particular interest for breast cancer researchers because they are prone to cancer in the exploration of breast catheters using high-resolution imaging techniques, researchers were surprised to discover a new type of immune cell and its special role in maintaining healthy, complete breast tissue "We found a whole new group of specialized immune cells, called catheter macrophages, which are squeezed between two layers of the breast catheter wall," says Dawon, a We are pleased to find that these cells play an important role at a critical time in the degradation of breast function when lactation stops, breast-producing cells die, and breast tissue needs to be reshaped to its original state We can't believe it to see star-shaped catheter macrophages using their arms to detect and devour dead cells The removal of catheter macrophages contributes to the collapse of excess milk-producing structures, allowing them to successfully return to a static state "
when researchers later removed macrophages from breast catheters, they found that no other immune cell could quickly complete this important process understand breast biology
most organs in the body, including the brain, liver, lungs, skin and intestines, have their own groups of macrophages -- macrophages from Greece, meaning "big phagop." These cells play an important role in regulating infection, inflammation and organ function in their location Professor Vivader said the discovery of mammary catheter-specific macrophages was an important step in understanding how the immune system interacts with the catheter network and affects breast development "As breast cancer researchers, it's important to know what cells are doing so that we can determine how these complex cellular processes become dysfunctional, such as in the case of breast cancer," she said "
explore the link between cancer
more than 19,000 Australians are diagnosed with breast cancer each year This is the most common cancer among Australian women Dr Dawon, , said the team hopes to explore the function of catheter macrophages at different stages of breast development, such as adulthood and pregnancy "We also want to study the role of these catheter-specific immune cells in helping cancer grow and spread," he said "
macrophages are spread throughout the mammography As cancer develops, so does the number of macrophages Dr Dawon said: "We suspect that macrophages may inadvertently weaken the body's immune response, which can have a dangerous effect on the growth and spread of cancer in these prone sites Professor vivader, , said the team's ultimate goal was to fully understand the cells so that they could be operated "Given that tumor macrophages may promote the growth of tumor , blocking their activity can be a treatment strategy for breast cancer (biovalleybioon.com) References: New Type of immune cell dicovered in breat Tiue-reident al macrophage urvey the mammary epithelium and the amitiueling , Cell Biology (2020) DOI: 10.1038/41556-020-0505-0