Nat Cell Biol: How do cancer cells protect themselves from harm?

4, 2020 // -- In a recent study published in the international journal Nature Cell Biology, scientists from the University of Sydney and others found that cancer cells may be able to repair their DNA using "cables" in their nuclea, which could help scientists develop new cancer therapies.
researcher Professor Noa Lamm said: 'In this study, we shed light on the new molecular mechanisms by which cancer cells repair and replicate DNA, and we spent more than four years revealing new features of actoprotein, a special protein that interacts with myoprotein, which helps muscles contract, while actoprotein also forms a "cable" structure within the cell that functions like a building beam, helping to shape and shape cells.
Photo Source: Lamm et al. Researchers have spent decades making it clear that actoprotein may play a key role in cell nucleases, but its key role in the nucleation of cells has been controversial in the scientific community; to advance cancer, cancer cells must make more copies, and DNA in the nuclea of cancer cells must be copied once each time new cancer cells are produced.
it's not clear whether the amygdoprotein played a role in DNA replication in cancer cells, after researchers found that the protein may have unexpected nuclear functions, and new research in this paper suggests this prediction is correct.
The replication of DNA in cancer cells is like an old car traveling at the highest speed, often breaking down and needing to be restarted, and cancer chemotherapy uses this weakness of cancer cells to make the process frequently destroy and destroy cancer cells.
researchers found that when cancer cells experience DNA replication problems, the titular protein cable is formed in the nuclea, which allows the nuclea to change shape and increase the cell's ability to replicate its DNA and re-open the replication process.
Using advanced ultra-resolution microscope technology, the researchers found that damaged DNA molecules move along the network of actoproteins to the most effective areas of the nuclea, after researchers did not know that cancer cells protect themselves in this way, and crucially, the researchers found that acting unexpectedly after responding to chemotherapy may have an unexpected effect and help cancer cells resist therapeutic attacks. the
researchers believe the findings may help cancer patients in two ways: first, the treatment of inactivated myocardial protein cable mechanisms or the killing of cancer cells that are difficult to maintain high-rate DNA replication;
the results of this paper may help develop new ways to treat cancer, and they will continue to explore and develop more anti-cancer therapies at a later stage, the researchers said.
original source: Lamm, N., Read, M.N., Nobis, M. et al. Nuclear F-actin counteracts nuclear deformation and promotes fork repair during replication stress. Nat Cell Biol 22, 1460–1470 (2020). doi:10.1038/s41556-020-00605-6。