Nat cell biol: heavyweight! First time! Scientists have successfully developed human immune cells in a dish!

January 15, 2020 / BIOON / -- in the future, scientists may use patients' own skin cells to generate new cells for cancer immunotherapy or intervention measures to detect autoimmune diseases Recently, an international journal Nature Cell Biology was published In the report above, scientists from Murdoch children's Institute have successfully cultivated human immune cells in a dish for the first time in the world Source: researchers at Murdoch children's Research Institute (MCRI) now have solid evidence to reveal how early immune cells in the body were formed by cells that formed the first organ of the embryo, rather than by hematopoietic stem cells in the body's bone marrow In this paper, researchers developed new stem cells by using two powerful laboratory techniques First of all, the researchers engineered the pluripotent stem cells When the special early marker named RAG1 in the early immune cells is turned on, these pluripotent stem cells will emit green light RAG1 is responsible for the immune response of the body against infection and vaccine The researchers then isolated and analyzed the glowing RAG1 positive cells and found that they were able to form a variety of immune cell types, including those needed to shape the overall immune system Professor Stanley, the researcher, said that these early cells are crucial for the maturation of the thymus, a key organ that can serve as a "nursery" for T cells These RAG1 are like painters and decorators in the process of building a "baby sitter", which can provide a safe and comfortable environment for later born immune cells Although it may take many years for the relevant research results to enter the clinical application, the results of this study may help scientists understand the pathogenesis of diseases such as childhood leukemia and type 1 diabetes At present, researchers are carrying out more in-depth research to find out the mystery Original sources: motazedian, A., bruveris, F.F., Kumar, S.V et al Multipotent RAG1 + agents emerge directly from haemogenic endotherium in human pluripotent step cell derived haematopoietic organizations NAT cell biol 22, 60 – 73 (2020) doi: 10.1038/s41556-019-0445-8