-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
During development, mammalian embryonic stem cells can unilaterally differentiate into various cell lines of the adult body
.
However, there is a reserve of tissue-specific adult stem cells in adults, which remain undifferentiated and are ready to differentiate into tissue-specific cell types to maintain balance or repair damaged tissues
stem cell
In the central nervous system (CNS), the most extensive and abundant adult stem cell population is OPC
.
After adulthood, OPCs renew themselves, mainly producing new myelin oligodendrocytes, but can also produce astrocytes and Schwann cells
With age, the ability of OPCs to self-renew and differentiate into myelin oligodendrocytes is greatly reduced.
Adult somatic cells can be reset to the embryonic state by the pluripotency factors Oct4, Sox2, KLF4 and c-Myc (OSKM factor), eliminating all the characteristics of cell aging
.
Recently, studies have shown that transient expression of OSKM factor can partially reprogram aging cells into a younger and more vigorous state, thereby extending life span and restoring tissue regeneration
Researchers have recently conducted an inquiry to verify whether aging OPCs (aOPCs) can be rejuvenated by partial reprogramming, what factors are needed to achieve this goal, and whether this leads to remyelination in the aging central nervous system ’S enhancement
Overexpression of c-MYC can reactivate senescent glial cell progenitor cells
c-MYC overexpression can reactivate senescent glial cell progenitor cells c-MYC overexpression can reactivate senescent glial cell progenitor cellsResearchers found that one of these reprogramming factors itself, c-Myc, is sufficient to determine the age status of OPC: c-Myc expression in elderly OPCs drives their functional recovery, and its inhibition in newborn OPCs Will induce a phenotype similar to aging , which is determined by in vitro experiments and transcriptome analysis
The expression of c-Myc in elderly OPCs drives their functional recovery, and its inhibition in newborn OPCs will induce a phenotype similar to aging.
Increasing the expression of c-Myc in the elderly OPCs in vivo can restore their proliferation and differentiation ability, thereby enhancing the regeneration ability in the environment of the elderly central nervous system .
Original source:
Original source:Björn Neumann et al.
Björn Neumann et al.
Leave a message here
