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The human lipoprotein E (APOE) gene has three main alleles-ε2, ε3, and ε4, of which ε3 is the most common
.
APOE ε4 is the strongest genetic risk factor for sporadic Alzheimer's disease, which increases the risk in a dose-dependent manner (3-4 times for ε4 heterozygotes; 12-16 times for ε4 homozygotes), and can lead to early dementia Seizures
APOE ε4 is the strongest genetic risk factor for sporadic Alzheimer's disease, increasing the risk in a dose-dependent manner APOE ε4 is the strongest genetic risk factor for sporadic Alzheimer's disease, increasing the risk in a dose-dependent manner
At present, the role of apoE in the pathogenesis of Alzheimer's disease is not fully understood, but ε4 is related to the reduction of β-amyloid clearance, and thus the accumulation of β-amyloid
.
The pathological changes of β-amyloid protein can be detected twenty or thirty years before the onset of symptoms.
However, it is reported that ε4 carriers have a variety of different survival advantages, including improved fertility, resistance to infection, reduced perinatal and infant mortality, and some minor cognitive advantages
.
APOE ε4 may be an example of resistance polymorphism-the main evolutionary explanation for aging and non-communicable diseases, that is, a gene has both beneficial and harmful effects, and the latter generally manifests in the later stages of life.
ε4 carriers have a variety of different survival advantages, including increased fertility, resistance to infection, reduced perinatal and infant mortality, and some minor cognitive advantages
The relationship between the β-amyloid burden of APOE ε4 carriers (n = 120) and non-carriers (n = 278) and the positioning error of the "what is?" task
.
.
The relationship between the β-amyloid burden of APOE ε4 carriers (n = 120) and non-carriers (n = 278) and the positioning error of the "what is?" task
APOE ε4 and β-amyloid have opposite effects on object recognition, indicating better and worse recall, respectively.
Original source:
Original source:Kirsty Lu et al.
Kirsty Lu et al.
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