-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Artistic picture of the nanotrap.
The core of the nanotrap is yellow, the phospholipid shell is green, the functionalized particles are red, and the virus protein shell is gray.
Image source: Huang Lab.
Researchers from the Pritzker School of Molecular Engineering at the University of Chicago have designed a new and promising treatment for new coronary pneumonia: nanoparticles can capture the new coronavirus in the body and then use the human immune system to destroy it.
These nanotraps can attract viruses by mimicking the target cells infected by the virus.
When the virus is combined with the nanotrap, the trap will isolate the virus from other cells and use it as a target for destruction by the immune system.
Theoretically, these nanotraps can also be used for virus variants, resulting in a new method of inhibiting virus development.
Although this therapy is still in the early testing stage, the researchers envision that it can be used to treat new coronary pneumonia through nasal spray.
Related papers were published in the recent "Substance".
"Since the start of the new coronary pneumonia pandemic, our team has been developing this new method
for the treatment of new coronary pneumonia.
" said assistant professor Huang Jun (transliteration) who is in charge of this research.
"We have conducted rigorous tests to prove these nano traps.
They are effective and we are excited about their potential.
"In order to design nanotraps, a research team led by postdoctoral scholar Chen Min (transliteration) and graduate student Jill Rosenberg studied the binding mechanism of the new coronavirus to cells: the spike protein on its surface.
, Binds to the ACE2 receptor protein of human cells.
Therefore, they designed nanoparticles with high-density ACE2 protein on the surface and nanoparticles with neutralizing antibodies on the surface.
When a person is infected, these antibodies are produced in the body and attach to the coronavirus in various ways.
Both the ACE2 protein and neutralizing antibodies have been used in the treatment of new coronary pneumonia, but by attaching them to nanoparticles, researchers have created a more powerful system for capturing and eliminating the virus.
Nanoparticles are made of FDA-approved polymers and phospholipids, and have a diameter of about 500 nanometers—much smaller than cells.
This means that nanotraps can reach more areas of the body and capture viruses more effectively.
The researchers tested the safety of the system on a mouse model and found no toxicity.
Then, they tested the nanotraps against the pseudovirus in human lung cells in tissue culture plates and found that they completely prevented the pseudovirus from entering the cell.
Pseudovirus is a virus model without the ability to replicate.
Related paper information: http://dx.
doi.
org/10.
1016/j.
matt.
2021.
04.
005 2020 hot articles selection 1.
Cup! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
The core of the nanotrap is yellow, the phospholipid shell is green, the functionalized particles are red, and the virus protein shell is gray.
Image source: Huang Lab.
Researchers from the Pritzker School of Molecular Engineering at the University of Chicago have designed a new and promising treatment for new coronary pneumonia: nanoparticles can capture the new coronavirus in the body and then use the human immune system to destroy it.
These nanotraps can attract viruses by mimicking the target cells infected by the virus.
When the virus is combined with the nanotrap, the trap will isolate the virus from other cells and use it as a target for destruction by the immune system.
Theoretically, these nanotraps can also be used for virus variants, resulting in a new method of inhibiting virus development.
Although this therapy is still in the early testing stage, the researchers envision that it can be used to treat new coronary pneumonia through nasal spray.
Related papers were published in the recent "Substance".
"Since the start of the new coronary pneumonia pandemic, our team has been developing this new method
for the treatment of new coronary pneumonia.
" said assistant professor Huang Jun (transliteration) who is in charge of this research.
"We have conducted rigorous tests to prove these nano traps.
They are effective and we are excited about their potential.
"In order to design nanotraps, a research team led by postdoctoral scholar Chen Min (transliteration) and graduate student Jill Rosenberg studied the binding mechanism of the new coronavirus to cells: the spike protein on its surface.
, Binds to the ACE2 receptor protein of human cells.
Therefore, they designed nanoparticles with high-density ACE2 protein on the surface and nanoparticles with neutralizing antibodies on the surface.
When a person is infected, these antibodies are produced in the body and attach to the coronavirus in various ways.
Both the ACE2 protein and neutralizing antibodies have been used in the treatment of new coronary pneumonia, but by attaching them to nanoparticles, researchers have created a more powerful system for capturing and eliminating the virus.
Nanoparticles are made of FDA-approved polymers and phospholipids, and have a diameter of about 500 nanometers—much smaller than cells.
This means that nanotraps can reach more areas of the body and capture viruses more effectively.
The researchers tested the safety of the system on a mouse model and found no toxicity.
Then, they tested the nanotraps against the pseudovirus in human lung cells in tissue culture plates and found that they completely prevented the pseudovirus from entering the cell.
Pseudovirus is a virus model without the ability to replicate.
Related paper information: http://dx.
doi.
org/10.
1016/j.
matt.
2021.
04.
005 2020 hot articles selection 1.
Cup! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
