Nano Today: PtCu alloy nanoenzyme is expected to treat Parkinson's disease

Parkinson's disease (PD) is the most common neurodegenerative disease characterized by the misfolding and accumulation of α-synaptic nucleoproteins (α-syn) in the LB.
some Parkinson's cases are related to familial PD, most cases are exudable and the cause is unclear.
recently, scientists have fundamentally upended previous understandings of α PD, a viral-like prion-like protein that moved the pathogenesis of PD.
, many studies have shown that elevated oxidative stress levels are the key cause of α-synth nuclear protein proliferation.
if we can find a substance that reduces oxidative stress levels, stop the α of misfolded synaptic nucleoproteins.
a recent study published in the journal Nano Today, researchers developed a nanoenzyme that blocks the spread of misfolded α-synaptic nucleoproteins and may lay the groundwork for the development of new PD therapies.
nanoenzyme is a PtCu alloy nanoenzyme made up of platinum and copper, which is biocompative and has strong antioxidant properties.
nanoenzymes are a class of nanomaterials that simulate the catalytic activity of bioenzymes and have many advantages that are incomparable to natural enzymes, so far, scientists have discovered hundreds of nanoenzymes with catalytic properties of steroids.
researchers used α-synactical nucleoprotein prefabribrio (PFF) models that replicate the pathology and neuropathy of Parkinson's disease induced by LB.
addition of PFF to neuron cell cultures, ros levels increased and α-synaptic nucleoproteins ad accumulate, presenting pathological and neurotoxicity.
Then, when PtCu alloy nanoenzymes are added, not only can the ros level be significantly reduced, the pathology and neurotoxicity of α-synth nucleoproteins are reduced, but more importantly, the spread of pathological α-synth nuclear proteins between cells, as well as the spread from synths to dark matter.
PtCu NAs reduce PFF-induced reactive oxygen species (ROS), co-pathology and neurotoxicity, and increasing studies have shown that deformed and misfolded α-synaptic nucleoproteins are the culprits of Parkinson's disease, spreading from the intestines to the brain, spreading and sticking together in the brain to form deadly clumps.
researchers hope to further research on intestinal and Parkinson's disease and provide new treatment strategies for Parkinson's disease treatment.
, PtCu alloy nanoenzymes showed significant efficacy in preventing the spread of α-synaptic nucleoproteins in exudable PD, providing a new strategy for the treatment of Parkinson's disease.