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On September 15, 2022, Shen Hongbing and Hu Zhibin's research group at the School of Public Health of Nanjing Medical University published a report entitled "Analyses of rare predisposing variants of lung cancer in 6004 whole genomes in" in the top international onc Chinese ology journal "Cancer cell" Chinese) research papers
Lung cancer is the malignant tumor
Shen Hongbing and Hu Zhibin's research group applied large-scale whole-genome sequencing (WGS) technology to NSCLC's genome-wide association research for the first time, which not only built a high-quality haplotype reference library specific to the Chinese group, but also newly discovered multiple common and low-frequency susceptibility variations associated with NSCLC.
The study successfully applied whole genome sequencing to lung cancer genomics research, systematically discovered common/low-frequency susceptibility variants and rare pathogenic variants of lung cancer, provided new ideas for comprehensively revealing the genetic patterns of lung cancer, and also provided a large number of candidate variants