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According to the World Health Organization (WHO), anemia affects more than 40% of children under the age of 5 in the world.
Long-term anemia in young children is related to poor health and developmental delay
.
Therefore, countries around the world (especially countries with a high incidence of anemia) have generally implemented interventions, and it is recommended that all young children be provided with iron supplements to prevent anemia
Anemia may affect the baby's mental state, appetite and immunity; many professionals believe that if iron is not supplemented in time, it may damage the baby's cognitive development and affect the child's intelligence and brain development
.
However, for decades, few studies have explored whether iron has a positive effect on children's development
A recent study published in The New England Journal of Medicine showed that although taking iron can improve children's anemia, it has no effect on children's cognitive function, behavior or development
.
Screenshot source: NEJM
Study included 3300 large 8-month-old baby, the baby has not been diagnosed with severe anemia (hemoglobin levels below 8.
0 g / dL), fever, severe acute malnutrition (stunting), hereditary red blood cell diseases
.
All babies are randomly divided into three groups (as shown in the figure below):
The first group took 12.
5 mg of iron (syrup) daily (1101 infants),
The second group took a variety of micronutrient powders daily, including iron 12.
5 mg, vitamin A 0.
3 mg, vitamin C 30 mg, 0.
16 mg folic acid, and 5 mg zinc (1099 infants).
The third group took placebo daily (1100 infants)
.
▲ Experimental design (picture source: reference [1])
The intervention lasts for 3 months
.
The research team evaluated the short-term and long-term effects of iron supplementation.
After the intervention, it was found that compared with the placebo group:
After completing the 3-month intervention, no significant effect of iron or multiple micronutrient powders on the infant’s comprehensive cognitive score was observed
.
The prevalence of anemia in infants in the three groups was reduced
Nine months after the completion of the intervention, no significant effects of different iron supplementation interventions on any other developmental or growth outcomes were observed
.
The prevalence of anemia, iron deficiency, and iron deficiency anemia in infants in the three groups increased, but the prevalence of infants who received iron or multiple micronutrient powders was lower than that of the placebo group
The risk of serious adverse events and the incidence of infection symptoms in the three experimental groups were similar
.
Approximately 2% of infants experienced at least one serious adverse event, and approximately 2% of patients were hospitalized
(The original text has been deleted)
Reference
[1] Pasricha S, et al.
[2]Iron Intervention No Boon for Baby's Cognitive Development.
