Multiple articles explain the mysterious link between Helicobacterrobacteria and stomach cancer!

We all know that Helicobacter pyridosis is the culprit in many cases of stomach cancer, in recent years, scientists through in-depth research revealed the bacteria induced stomach cancer a variety of pathogenic factors, in this article, the small editor on the compilation of relevant research results, with you to learn! FILE PHOTO: PLoS Biol: Discover that Helicobacter pyridobacteria is a safe haven deep in the stomach glands doi:10.1371/journal.journal.pbio.3000231 For a long time, scientists have been trying to understand how pathogenic bacteria like Helicobacter pyridosis survive in harsh environments of the stomach.
Helicobacter pyridobacteria is a risk factor for stomach ulcers and stomach cancer, and researchers at Stanford University suggest in a new study published in the open-access journal PLoS Biology that Helicobacter pyridobacteria uses a special ecological position in the stomach glands to provide itself with a safe haven to maintain a lifetime of settlement.
researchers say helicobacter pythrobacteria clings to epithal cells deep in the stomach glands.
researchers speculate that this location may protect these bacteriums from the constant turnover of bacteria on the surface of the stomach, making them a stable reservoir of bacteria.
To determine how Helicobacteria builds, spreads, and persists in the stomach glands, the researchers used high-resolution imaging and mapping techniques to observe these gland-related populations in animals with helicobacter helicobacteria mixed with different fluorescent markers.
researchers used a technique called passive transparency to treat infected stomachs, which makes tissues transparent.
allows researchers to image complete organs as a whole.
found that a small number of bacteria act as "starters" to build, replicate and form bacteriums in a single stomach gland.
, the bacteria spread to the adjacent glands, forming a large population of asexual systems, forming "islands" of the same color as the original glands.
these population islands will persist over time and prevent any foreign bacterial drops in the glands.
: Oncogene: 40 years apart! Scientists shed light on the new molecular mechanism of Helicobacter pyridobacteria that causes stomach cancer doi:10.1038/s41388-019-0702-01982, when researchers discovered a link between chronic gastritis and Helicobacter pyridosis. Helicobacterrobacteria is a large number of studies, the results show that, in addition to causing gastritis, Helicobacterrobacteria is also a key factor in inducing stomach ulcers and stomach cancer, researchers have clearly clarified the link between this bacteria and a variety of stomach diseases, but how Helicobacteria in the end induced stomach tumors, there is still a lot of controversy in the scientific community.
Forty years later, scientists from Japan's Miyazawa University and others have revealed that inflammation caused by Helicobacter pyridobacteria promotes the proliferation of upper-corted stem cells in the stomach, which in turn triggers the molecular mechanisms of stomach tumors, according to research published in the international journal Oncogene.
, the researchers describe how they have made breakthrough new discoveries based on previous research. 'Previously, we've found that tumor necrotic factor α (TNF-α), which promotes inflammation in the body, may promote the production of stomach tumors by activating the function of the NOXO1 protein, but we don't know how NOXO1 induces stomach tumors,' said
researcher Dr. Canae Echizen.
NOXO1 is a component of the NOX1 complex, which produces tissue-damaged molecules - reactive oxygen (ROS), and the oxidative stress reaction caused by ROS triggers mutations in DNA in stomach cells, triggering tumor formation, and inflammation caused by Helicobacter pyridosis infections also produces ROS, which increases oxidative stress in the stomach.
: Special small RNA molecules play a key role in Helicobacter pyridobacteria infection in humans doi:10.1016/j.molcel.2020.09. 009 More than half of the world's body's stomach mucous membranes carry Helicobacter pyridobacteria, which usually does not cause any health problems in a person's lifetime, but sometimes Helicobacter pyridosis can cause inflammation of the body, and may even lead to stomach cancer.
Helicobacterrobacteria can use toxic factors to survive and induce disease in the stomachs of carriers, and in a recent study published in the international journal Molecular Cell, scientists from the University of Welzburg and others found that multiple toxic factors in Helicobacteria can be centrally regulated by small RNA molecules called NikS.
The target gene regulated by NikS is an important toxic factor for Helicobacter pyrethroids and two genes that encode exome proteins, especially since the researchers found that NikS regulates the expression of the CagA protein, a bacterial cancer protein that plays a key role in the development of Helicobacter pyridobacteria-induced cancer, and an unknown function protein secreted by Helicobacter pyridobacteria is released into the environment.
researcher Cynthia Sharma explains that the findings are of great importance for both medical research and the study of infectious diseases, and that by understanding the different functions and molecular mechanisms of this small RNA molecule and its associated bacterial signaling pathras during infection, researchers may be able to find new targets to develop new antimicrobial therapies.
: Cell Host and Micro: Revealing that Helicobacter pyridobacteria shuts down the energy production process of the mucous membrane cells of the host stomach to establish the molecular mechanism of long-acting infection doi:10.1016/j.chom.2018.04.006 Recently, a study published in the international journal Cell Host In the Microbe study, scientists from the University of Illinois at Urbana-Champaign found that Helicobacter pyridobacteria, which is a cause of gastritis, stomach ulcers and stomach cancer, can act as a natural barrier against infection by turning off the body's energy production from mucous membrane cells in the body.
-related research may help researchers better understand the pathogenic mechanisms of Helicobacter pyrethrobacteria, while developing new therapies to fight infections caused by Helicobacter pyrethrobacteria.
researcher Professor Steven Blanke says Helicobacterrobacteria can infect half of the world's population and induce gastritis, and the bacteria can spread from person to person, usually two years before infection, with long-term infections in patients continuing for ten years and most patients not developing any symptoms of infection until the disease develops into late stages.
: PLoS Pathog: Nobel Prize-winning heavyweight article Interpreting the molecular mechanism of Helicobacter pyridoccol survival in the stomach doi:10.1371/journal.ppat.1006280, from the University of Western Australia and many others The agency's researchers delved into the fine structure of helicobacter pyridobacteria, an important pathogenic bacteria that induces stomach ulcers in the body, in a study published in the international journal PLoS Pathogens that could offer hope for later researchers to develop new treatments for stomach ulcers.
Helicobacter pyrethroide, discovered by scientists Barry Marshall and Robin Warren, was able to infect stomach tissue and cause ulcers, and the two researchers won the 2005 Nobel Prize in Physiology and Medicine for their discovery of Helicobacter pyrethroe.
In the latest study, researchers say they have delved into the enzymes and structures responsible for the production of Helicobacter pyridobacteria polysaccharides, a special fat polysaccharide molecule that covers the entire bacterial cell surface like a protective shield and has certain properties compared to other bacteria that help bacteria invade the body's natural immune system to induce long-term infections.
photo source: lb.wikipedia.org: Nat Microbiol: Scientists clarify that helicobacter pyridobacteria new-polymer new-polymer new therapy development promises doi:10.1038/nmicrobiol.2016.189 Helicobacter pyro In a study published in the international journal Nature Microbiology, researchers from the University of Technology in Munich and others have found a new way to suppress or treat infections or complications caused by Helicobacterrobacteria.
Helicobacterium infection usually occurs at an early age and is widely distributed, with many people carrying the bacteria, which can cause complications including gastritis, stomach ulcers and heterointestinal ulcers, in addition to increasing Carriers have a risk of stomach cancer, the current treatment of Helicobacterium is typical of antibiotic treatment, but the lack of antibiotic therapy lies in its destruction of bacteria at the same time will affect the normal gastrointestinal tract, but also increase Helicobacterrobacteria resistance to antibiotics.
In order to survive in the human stomach for a long time, Helicobacter pyridobacteria must be adsorbed to the epithelial cells of the stomach mucous membrane, and the researchers in the paper detected a significant change in the specificity of helicobacter pyridobacteria adsorption in epithelial cells, where the molecule HopQ on the bacterial surface can bind to cancerous embryo antigen-related cell adhesive molecules (CEACAMs); Singer said the binding does not depend on the structure of sugars compared to previously known bacterial binding partners, which seems to indicate that bacteria maintain specific stability in the acidic environment of the stomach, and CEACAMs do not appear in healthy stomach tissue, but CEACAMs do occur when Helicobacter pyridosis causes inflammation in the stomach.
: Identify new targets for fighting Helicobacter pyridobacteria infection doi:10.1126/ sciadv.aav8423 More than half of the world's population has a type of infection in their stomachs called Helicobacterrobacteria bacteria, although harmless to many people, but Helicobacterrobacteria can cause stomach cancer, stomach ulcers and other stomach diseases, clinicians are now more inclined to give patients a variety of antibiotics to resist the bacteria, but this strategy often leads to Helicobacteria antibiotic resistance.
In a recent study published in the international journal Science Advances, scientists from the University of California developed a new method by which researchers identified a special protein molecular structure that promotes helicobacter pyridoxine survival in the stomach, and the researchers explained the mechanism by which this particular protein worked.
researcher Z. Hong Zhou said the study promises to answer the question that scientists have been trying to solve since the discovery of Helicobacter pyridosis in 2005, because of its special urea channels, helicobacter pyridosis is often able to grow and reproduce in harsh environments in the stomach, and that special proteins in the bacterial endometrium can detect acidity in the environment and act as "doors" when the stomach environment is acidic As the degree increases, the urea channel in Helicobacter pyridoxine opens to allow urea compounds to enter the cells, and urea is normally excreted from the urine as waste, but researchers have also found smaller concentrations of urea in the stomach of the human body, and Helicobacter pyrethroids use urea as a raw material to protect against the acidic environment in which bacteria are killed in the stomach.
: Infect Immun: Uncovering the pathogenic mechanism of Helicobacter pyridobacteria doi:10.1128/IAI.00790-19 Recently, a study published in the international journal Infection and Immunity In a study entitled "Bacterial Energetic Requirements for Helicobacter pylori Cag Type IV Secretion System-Dependent Alterations in Gastric Epithelial Cells", scientists from Vanderburg University revealed the pathogenesis of Helicobacter pylori.
helicobacter pylori, which is planted in the stomachs of nearly half of the world's population, increases the risk of cancer in the population.
Helicobacter pyridobacteria contains a cluster of genes called cag PAI, which is directly related to the onset of high-risk stomach cancer, and these strains are capable of synthesized into a complex molecular machine called the IV secretion system (T4SS), which injects cancer proteins and other bacterial products called CagA into stomach cells.
.9 PNAS: Special drugs may be effective in suppressing gastric cancer by inducing helicobacter pyridoigen mutations: 10.1073/pnas.18144971116, an international journal Proceeding In a study published in the National Academy of Sciences, scientists from Vanderburg University Medical Center found that many types of drugs currently treated as a chemotherapy agent may also have great potential in treating stomach cancer; in addition to being known to block the growth of cancer cells, drugs called DFMO (difluoromethyl birdine) can directly reduce the toxicity of Helicobacter pylori, the main cause of stomach cancer.
Gastric cancer is the third major cause of death in cancer patients, and the findings support further research into how DFMO prevents stomach cancer; Helicobacter pyridosis infects half of the population, but only about 1% of those infected develop stomach cancer, and although we can prevent stomach cancer by treating infections, researchers don't know who to treat it, and helicobacter pyridosis can produce some beneficial effects