Multi-group studies have found potential targets for lung cancer diagnosis and treatment

Recently, the international medical journal Cancer Research published a research article by Professor Li Weimin, Dean of Huaxi Hospital of Sichuan University, and Professor Xie Dan, which integrated chromatin open sequencing (ATAC-seq), genome-wide sequencing, transcriptional group sequencing techniques, and found that lung cancer of different pathological types has its own unique chromatin open regional characteristics through multi-group sequencing of 50 non-small cell lung cancer tissues. This reveals the complex network of gene regulation in lung cancer, which lays an important foundation for the future development of new targeted drugs for lung cancer and helps to promote the establishment of new treatment and intervention models for lung cancer, Li said.

years, lung cancer genome sequencing research has revealed a link between some gene mutations and lung cancer, but there are still some lung cancer patients who do not have obvious driver gene mutations, but changes at the apparent genetic level, Li said. Among them, the open area of chromosomal is an important osteogenetic feature, and the existence of open chromosome often means the activation of the corresponding DNA regulatory elements, which can regulate downstream gene expression. In view of the complex gene regulation patterns, it is of great significance to integrate multi-group data such as genome, transcription group and exogenomic genetic group to reveal the complex gene regulation network of lung cancer from many levels.
The study found that the open areas specific to lung squamous cancer appeared around genes associated with the epithelocellular carnalization process, and the open areas specific to early lung adenocarcinoma appeared around genes associated with prognostication. Moreover, the researchers found a wide distribution of open areas in lung cancer samples, which were mainly found near the transcriptional starting point of the gene, which not only showed the characteristics of the cancerous species, but was also associated with the degree of confusion in gene expression. This phenomenon suggests that wide open areas may be involved in the process of tumor gene regulation disorders.
The study found 21 seats with a number of sexuality associated with genome open areas and transcript expression regulation. The study also confirms the pattern of places associated with lung cancer risk participating in genomic regulatory networks, as previously proposed in the analysis of lung cancer genome-wide associations. These regulatory positions and modes can be used as targets for lung cancer diagnosis and drug design to guide the precise treatment of lung cancer. (Health Journal)