Mult Scler: another big danger of obesity -- aggravating the condition of multiple sclerosis patients

June 10, 2019 / biool / - obesity is the aggravating factor of relapsing remitting multiple sclerosis (the most common disease) A recent study by the i.r.c.c.s Department of Neurology and neurorehabilitation in pozzilli, Italy, confirmed that lipid metabolism may play a role in determining the severity of multiple sclerosis The study, published in the multiple sciences journal, involved 140 patients Studies have shown that obese patients are at a higher risk of developing a higher EDSS (extended disability scale) score at the time of diagnosis EDSS is a common tool to evaluate the severity of multiple sclerosis Neurologists also looked at the biochemical relationship between multiple sclerosis and overweight, the level of inflammation in the central nervous system and the concentration of lipids (cholesterol and triglycerides) in the blood Photo source: http://cn.bing.com multiple sclerosis is an inflammatory process The authors of this study focused on some inflammation related molecules Cerebrospinal fluid analysis (lumbar puncture Collection) showed that the level of interleukin-6 (IL-6) and leptin were higher in obese patients, which were called the promoters of inflammatory process On the contrary, IL-13 with anti-inflammatory effect was decreased In the aspect of blood lipid, the higher triglyceride level and the higher ratio of total cholesterol to HDL cholesterol are related to the higher level of IL-6 "This study confirms that obesity is related to the severity of the symptoms of relapsing remitting multiple sclerosis," said Mario stampanoni Bassi, a neuroscientist in Neuromedicine The analysis of CSF in particular highlights the role of adipocytes in the production of leptin Previous studies have shown that leptin is directly involved in the complex relationship between metabolism and inflammation Therefore, our results show that overweight or changes in blood lipid levels are related to increased central inflammation, leading to worse clinical manifestations of the disease "It's important to accurately define the relationship between obesity, lipids and multiple sclerosis," said Diego Centonze, Professor of Neurology and director of Neurology at tor Vergata University "Weight and dyslipidemia are associated with a variety of chronic inflammation, but they are also strictly lifestyle dependent factors Therefore, specific strategies, such as diet or increased physical activity, may pave the way for improvement of the condition of patients with multiple sclerosis Over time, the number of people with disabilities will increase "Reference: Mario stampanoni Bassi et al, objectivity worsens central information and disability in multiple sciences, multiple sciences journal (2019) Doi: 10.1177/1352458519853473