Mov Disord: What is the basis of the gray matter structure of progressive supranuclear palsy and speech disorder?

Progressive supranuclear palsy (PSP) is a type of neurodegenerative tauopathy characterized by eye movement dysfunction, postural instability and falls, dyskinesia, and cognitive dysfunction
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Medullary symptoms often appear very early, can be severe, and are an independent predictor of survival.
It may be due to the increased risk of aspiration pneumonia due to physiological swallowing disorders, which is the most common cause of death in PSP
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Previous reports on PSP dysphagia have always been based on oral (relative to pharynx) disorders
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The severity of pharyngeal dysfunction and the degree of airway invasion are related to the severity of PSP disease
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In this way, Heather M.
Clark and others of the Mayo Clinic in the United States explored the relationship between gray matter volume and white matter duct integrity, oral and pharynx dysphagia, and airway invasion
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It also predicts that the oral phase disorder will be related to the high-level cortical swallowing network, and the pharynx phase disorder will be related to the brainstem pathway
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38 with progressive supranuclear palsy participants received video fluorescent FIG swallowing evaluation (videofluorographic swallowing assessment) as well as the structure and diffusion tensor MR imaging
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They found that the obstacles in the oral phase are related to the reduction of the top volume and the abnormal spread of the top and sensorimotor white matter, the hind limbs of the internal capsule, and the upper longitudinal tendons
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The important significance of this research lies in the discovery: the different patterns of neuroanatomical damage correspond to the dysphagia in the oral and throat stages
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Original source:
Clark HM, Tosakulwong N, Weigand SD, et al.