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Mov Disord: polygenic score, which can predict the incidence of Parkinson's

 Last Update: 2021-09-29
 Source: Internet
 Author: User

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Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by static tremor, stiffness, bradykinesia, and postural instability
.

The degeneration of dopaminergic neurons next to the substantia nigra is a histopathological sign of Parkinson's disease, which precedes clinical symptoms
.

Both genetic and environmental factors contribute to the occurrence of the disease, of which advanced age is the biggest risk factor

Genetic risk assessment provides an objective and quantitative probability of identifying high-risk populations before the onset of disease
.

Current methods lean toward the "common disease, common variant" hypothesis, in which low-risk alleles account for most of the genetic board widely known as the polygenic risk score (PRS)

So far, PRS has been proven to better estimate PD risk and monitor disease progression
.

Genome-wide association studies ( GWAS ) make it possible to identify these alleles; however, GWAS is largely limited to people of European descent

GWAS However, GWAS is largely restricted to people of European descent

They prospectively collected genetic, diet and life>
.

Construct PRS with Asia-specific and top-level genome-wide association research variants

After a follow-up period of more than 20 years, a total of 333 cases were found
.

After adjusting for diet and life>

The important significance of this study lies in the discovery: After adjusting for diet and life>
.

After adjusting for diet and life>
.

Original source:
Sia M, Foo J, Saffari S, et al.

Polygenic Risk Scores in a Prospective Parkinson's Disease Cohort.
Mov Disord.

Polygenic Risk Scores in a Prospective Parkinson's Disease Cohort.
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