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Mov Disord: Multi-target transcranial electrical stimulation, the treatment of frozen gait, how effective

 Last Update: 2021-09-29
 Source: Internet
 Author: User

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Frozen gait (FOG) is one of the typical symptoms of Parkinson's disease (PD)
.

Current treatment methods are limited and new therapies are needed
.

In addition to the subcortical dysfunction of the striatum and cerebellar motor area, recent studies have shown that FOG is also related to the dysfunction of the prefrontal lobe cognitive and sensorimotor networks

Transcranial direct current stimulation (tDCS) can adjust the excitability of cortical neurons and their connected neural networks
.

Pilot work has shown that TDCS aimed at promoting the excitability of the primary motor cortex (M1) can reduce FOG, and TDCS targeting the left dorsolateral prefrontal cortex (dlPFC) can improve executive function and cognitive requirements "dual-task" Gait under conditions, and TDCS can improve self-reported FOG severity

Brad Manor and others of the Hinda and Arthur Marcus Institute for Aging Research in the United States, in a pilot study of 20 PD patients with FOG, compared with M1 or sham stimulation, the left dlPFC and M1 were stimulated immediately after a single TDCS stimulation Significantly reduces the severity of FOG
.

The main analysis shows that TDCS has no advantage in the FOG induction test
.

In the secondary analysis, compared with the control, TDCS reduced the severity of self-reported FOG and increased the number of steps in daily life
.

In people with mild to moderate FOG severity, TDCS improved FOG induction test time and FOG self-report

Compared with the control, TDCS reduced the severity of self-reported FOG and increased the number of steps in daily life

Multi-course TDCS targeting the left dorsolateral prefrontal cortex and M1 did not improve the performance of laboratory-based FOG-induced tests
.

The improvement observed in participants with mild to moderate FOG severity deserves further study

Original Source:
Manor B, Dagan M, Herman T, et al.

Multitarget Transcranial Electrical Stimulation for Freezing of Gait: A Randomized Controlled Trial.
Mov Disord.
Published online August 18, 2021:mds.

Multitarget Transcranial Electrical Stimulation for Freezing of Gait: A Randomized Controlled Trial.
Mov Disord.
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