Mov Disord: In the mentally related symptoms of Parkinson's patients, the serotonin and dopamine production system is the "culprit"?

Parkinson's disease (PD) is characterized by progressive degradation of multiple monoaminergic systems, leading to a wide range of clinical manifestations
.
There is increasing evidence that the serotonergic and dopaminergic systems have an impact on these motor and non-motor disorders

At present, there are few studies analyzing and exploring the topography and evolution of serotonergic innervation
.

Recent work using PET-[11C]DASB has shown that PD is related to a specific mode of cooperation.

A longitudinal study used [123I]FP-CIT-SPECT to evaluate the xiphoid serotonin transporter density in early patients.
The results showed that during the 2-year follow-up, tremor was predominant and postural instability/gait disorder phenotype The binding rate gradually decreases
.

In this way, Audrey Maillet and others of 2Université Claude Bernard Lyon, France, used presynaptic dopaminergic ([11C]PE2I) and serotonergic ([11C]DASB) tracers combined with clinical and PET neuroimaging methods, Provide a clearer image of the double degradation process
.

To this end, they will compare the two groups of PD patients with a short course of disease, showing or not showing indifference, with patients with a medium and long course of disease
.
In addition, stratification based on the severity of neuropsychiatric manifestations that are independent of the course of the disease can help determine the pathophysiology of these symptoms

They conducted a cross-sectional study that combined clinical and dual-tracer positron emission tomography (PET) neuroimaging methods, using dopamine radioligand ([11 C]DASB) reuptake, in different courses of Pa Among patients with Kinsen's disease (ie short course of disease without medicine (n = 27, 0-2 years course), with apathy (n = 14) or none (n = 13); moderate course (n = 15, 4) -7 years disease course) and long disease course, patients without dementia (n=15, 8-10 years disease course))
.
At the same time, 15 age-matched healthy subjects were recruited

They found that:
(1) Dopaminergic and serotonergic lesions worsened with the duration of Parkinson's disease, spreading from the midbrain/subcortex to the cortical area;
(2) Parkinson's disease has apathy and more serious disease Cortex and subcortical serotonergic and dopaminergic destruction are related to the pattern of innervation observed in patients with moderate disease
.

Original Source:
Maillet A, Météreau E, Tremblay L, et al.
Serotonergic and Dopaminergic Lesions Underlying Parkinsonian Neuropsychiatric Signs .
Mov Disord.
Published online September 8, 2021:mds.
28722.
doi:10.
1002/mds.
28722