Molecular Psychiatry: In mice, scientists successfully reversed age-related memory loss!

Perineural network (PNN) is a structure containing chondroitin sulfate proteoglycan on the surface of neurons, which is related to neural plasticity and memory control

Wherein the chondroitin-4-sulfate, having the effect of inhibiting the network, can inhibit neuronal plasticity; andchondroitin-6-sulfate, may promote neuronal plasticity

A study published in Molecular Psychiatry on July 16, 2021 found that restoring chondroitin 6-sulfate (C6S) levels in elderly animals can rescue memory deficits and restore cortical long-term enhancement.

Restoring chondroitin 6-sulfate (C6S) levels in elderly animals on Molecular Psychiatry on Molecular Psychiatry can rescue memory deficits and restore long-term cortical enhancement.

In this study , the team observed 20-month-old mice , and compared with 6-month- old mice , these mice had memory deficits

In this study , the team looked at a large 20-month mouse , and the 6-month rat , and the six-month old mice old mice compared to the mice's memory defect occurs

ChABC injection rescues age-related OR memory deficits

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In order to further explore the chondroitin-6-sulfate in the role of memory loss effect of memory loss , researchers cultivated in mice after genetic manipulation ( chst3) changes to simulate aging

 

Age-mediated memory loss in C57bl/6 mice and restoration of SOR memory by injection of AAV1- Chst3 into PRh 

Age-mediated memory loss in C57bl/6 mice and restoration of SOR memory by injection of AAV1- Chst3 into PRhChst3

 Professor James Fawcett of the John van Geest Brain Repair Center at the University of Cambridge said: "It is exciting that although our research is only in mice, the same mechanism should work in humans- because of the structure of the human brain and the brain The molecule is the same as that of rodents , which suggests that it is possible to prevent memory loss in humans in old age

 Professor James Fawcett of the John van Geest Brain Repair Center at the University of Cambridge said: "It is exciting that although our research is only in mice, the same mechanism should work in humans- because of the structure of the human brain and the brain The molecule is the same as that of rodents , which suggests that it is possible to prevent memory loss in humans in old age

And the team has identified a potential drug, already approved for human use for human use , can be administered orally and inhibit the formation of PNN

Sujeong Yang et al, Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing, Molecular Psychiatry Molecular Psychiatry(2021).

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