Minimum limit of sufficient oxygen supply to maintain in vitro aerobic metabolism of newborns

background and purpose
In vitro circulation (CPB) is designed to provide oxygen (?) The right balance is maintained between O2) and oxygen consumptionCritical? O2means that oxygen consumption depends on oxygen supply at a certain amount of oxygen supplyThe purpose of this study is to determine the criticality of newborns with higher metabolic rates than adults? O2calculated according to the CPB parameters recorded during aortic blocking in this retrospective neonatal cohort study? O2The high lactic acid concentration (lactOFF) measured after the aorta is opened is used to identify anaerobic metabolismData analysis uses a hybrid linear proportional regression modelIn the lactOFF 2.5 mM subgroup (these children are thought to be in balance between oxygen supply and oxygen consumption), analysis? The relationship between theo 2 and temperature Estimated regression coefficients are further used to adjust assumptions? O 2 threshold and will it fall below the threshold? O 2 offset squanited as strength duration At 37 degrees C, the minimum threshold for providing strength duration is associated with an increase in lactOFF and is used as the minimum suitability (critical)? O 2 Results 22,896 points in 180 newborns were analyzed in this study 40 cases 2.5mM of children, ? O 2 changed 22.87 (0.70) ml -1 m -2 -c -1 change between 340-380ml min -1 m -2 ? O 2 threshold, the offset below the threshold is related to the increasing lactOFF min -1 m -
2 below 340ml ? The offset of 100 ml m -2 of the O 2 threshold increases the risk of increasing the lactOFF by 22% (OR: 1.22; 95% CI: 1.02 to 1.45) by increasing the risk of 1 mM in the lactOFF The results of the found that 340 ml of -1 m -2 may be the minimum suitable (critical)) required for newborns to maintain aerobic metabolism during the normal temperature CPB? O 2 Original Literature Abstract Bojan M, Gioia E, Di Corte F, et al.
Lower limit of the eose oedd for the maintenance of the aith ai ai ai ath ath ath ath ath ath.
Br J Anaesth 2020, 124 (
4): 395-402.
Background: the objective of cardio of the cardio-bypassary (CPB) is to the club an ei dol balance balance between oxygen delivery (? O 2 ) and sm The critical ? O 2 is that at what os ses sp sp This study aimed to identify the critical ? O 2 in snedd, whoe have higher sie simr san adults.
Methods: In a retrospective cohort of the new,??? O 2 wyth sydd from CPB parameters recorded yn aortic cross-clamping High lactate seiret spent dh'aortic unclamping (lactoff) was used to identify anaiai aithasm Data wasied yn ymchd yn ystod yn ystod The relationship between ? O 2 and sydd temperature oedd in a subgroup of patients with lactoff 2.5 mM, thought to have had balanced dywedodd oxygen and spent The estimated regression regression wass used to adjust ysto? O 2 thresholds, and? O 2 excursions below the threshold wase ei fod as shwedd as gymrions The lowest threshold that provided-magnitudes and linked with an an san a oed yn lactoff was used as the slowest annan (critical) ? O 2 37degrees.
Results: Overall, 22 896 time points were wereed in 180 sned In 40 patients with lactOFF 2.5 mM, ? O 2 varied by 22.87 (0.70) ml min -1 m -2 c -1 When varying the ? O 2 mee340 and 380 ml min -1 m -2 , excursions below the threshold bylysyn yddd i'r lactoff A 100 ml m -2 excursion below the 340 ml min -1 m -2 ? O 2 the risk of a 1 mM increment in lactoff by 22% (odds ratio: 1.22; 95% confidence interval: 1.02 to 1.45), Conclusions: It was found that 340 ml min -1 m -2 is likely to the slowest slear tha iad? O 2 needed in the ensto to the saitad iad iad i nonormomic CPB anesthGH Source: Poppy