Midology: Perioperative use of Pribarin and ketamine to prevent persistent pain after heart surgery

Persistent pain after surgery is common and affects the quality of life of patientsThis study hypothesizes that the use of pregabinander and ketamine canprevent persistent pain afterheart surgerythe randomised, double-blind, placebo-controlled trial was conducted at two heart surgery centres in the UKAdults without chronic pain and patients who underwent any elective heart surgery through thoracic incision were randomly assigned to receive the usual care, using pre-gabarin alone (150 mg before surgery, twice a day for 14 days after surgery), or pre-plus Barin combined with 48 h intravenous ketamine after surgery at a dose of 01 mg kghThe primary endpoint was the incidence of clinically significant pain for 3 months and 6 months after surgery, defined as the 3 largest cough function assessments, and the pain score on the numerical scoring table was 4 or higher (10 out of 10)Secondary outcomes include acute pain, opioid use and safety measures, as well as long-term neuropathic pain, analgesic needs, and quality of liferesults, a total of 150 patients were randomized, 17 patients withdrew from treatment and 2 patients were visited, but data on all participants were analyzed for intentional treatmentWith the control group (34 per cent of the 50 people of 17 people); OR s.126 (0.022 to 0.5), P-0.0008; and 0.041 (0.0009-028, P.0001) patients in the group of patients who used Pribarin alone (3 out of 50) and combined with ketamine (2 per cent of 50) at 3 months after surgery The incidence of pain is low; at 6 months, with the control group (28 per cent of the 50 people, 14 out of 50), OR, or, 0.029 to 0.7, P, 0.006, and 0.000 The incidence of pain was lower in patients in the group with pre-use plus Bahrain (6% of the 50 people) and 0% (0 out of 5) compared to P .0001), the results show that taking 150 mg pregabalin before surgery and continuing to take it twice a day for 14 days can significantly reduce the incidence of persistent pain after heart surgery