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Tumor metastasis causes up to 90% cancer-related mortality, and circulating tumor cells ( CTC ) are tumor cells that are shed from the primary tumor and released into the blood circulation, and play the same role as seeds in the process of tumor metastasis, enabling accurate detection of circulating tumor cells have important clinical value
.
Clinical studies have shown that the number of CTCs in cancer patients correlates with the disease, which can indicate disease progression and evaluate treatment effects
Recently , Zhou Lianqun 's team from Suzhou Institute of MedicalTechnology, Chinese Academy of Sciences innovatively developed a new technology for membrane filtration and enrichment that can realize fast, efficient and non- clogging CTC .
Included, doctoral student Li Hao is the first author, and researcher Zhou Lianqun and Zhang Wei are the corresponding authors .
In this study, inspired by the windmill airflow disturbance model in nature, researchers developed a novel integrated microdevice of a pinwheel-like array membrane for efficient, clogging-free and self-mixing enrichment of circulating tumor cells
.
The pinwheel-like hole array design on the negative photoresist ( SU-8 ) enables the cells to be dispersed evenly and reduces the pressure of the fluid on the cells
In recent years, the team has gradually deployed in the direction of liquid biopsy of tumors.
Currently, it has independently developed a high-throughput multi-channel circulating tumor cell detector.
In the future, it will carry out research on circulating tumor DNA ( ctDNA ) and exosomes, gradually moving from laboratory verification to laboratory verification.
The research was funded by the Key R&D Program of the Ministry of Science and Technology, the National Natural Science Foundation of China, the Major Scientific Research Instrument and Equipment Development Project of the Chinese Academy of Sciences, the Youth Innovation Promotion Association of the Chinese Academy of Sciences, and the Key R&D Program of Jiangsu Province
Paper link: https://
Figure 1.
Fig.
Figure 3 Comparison of cell distribution on different types of well array membranes
Figure 4 Validation of clinical samples, an assay using blood from different cancer patients to capture CTCs
