Metabolites: Bile acid may play a magical role in the onset of Parkinson's disease!

February 5, 2021 // -- In a recent study published in the international journal Metabolites, scientists from the Winnello Institute and others in the United States found that bile acid is produced or plays an unknown role in the course of Parkinson's disease; The researchers found that changes in the gut microbiome may alter the production of bile acid by promoting the synthesis of toxic forms of acid.
This change is only visible in patients with Parkinson's disease and does not exist in healthy controlled populations; a key difference suggests that bile acid may be a visible biomarker for early diagnosis of Parkinson's disease and tracking its progression, and studies have found or are expected to help develop new therapies to block intestinal changes associated with Parkinson's disease, potentially slowing or blocking the onset and development of the disease.
Photo Source: Wikipedia researcher Dr Peipei Li says it is becoming increasingly clear that intestinal health is closely linked to brain health; this study provides new opportunities to help us better understand the link and develop new therapies that can diagnose and even treat Parkinson's disease.
to investigate differences in the microbiome, the researchers turned to the appendix, a tissue in the body that is often destroyed and actually plays an important role in regulating the gut microbiome.
Using a multi-histological approach, the researchers comprehensively analyzed and compared the composition of microbiomes in the appendix tissues of Parkinson's disease patients and healthy people, and found significant differences in the composition of microbiomes in appendix samples of Parkinson's disease patients, which were closely related to high levels of toxic bile acid.
that changes in bile acid in plasma are closely related to the occurrence of Parkinson's disease.
researcher Stewart Graham said: 'Our lab is very interested in studying the association between bile acid and parkinson's disease in the body, not only because of the changes we induce in the brain that lead to significant changes in bile acid metabolism, but also because these compounds can also be used as biomarkers of early blood to indicate the disease.
In recent years, many studies have revealed a link between the gut and Parkinson's disease, such as chronic constipation, which is considered the earliest sign of Parkinson's disease and exists years before the disease's signature motor symptoms appear, and other studies have shown that hepatitis C, which affects liver function, also increases an individual's risk of parkinson's disease.
importantly, researchers in 2018 found that surgical removal of appendix tissue in an individual's early years may reduce an individual's risk of Parkinson's disease by 19-25%, in addition to the appendix tissue or Parkinson's disease-related protein- α synapses The accumulation of α synth nucleoproteins in the warehouse of nuclear proteins is a key pathological feature of Parkinson's disease, but researchers have found α synactical nucleoproteins in health-controlled individuals and in appendix tissue in patients with Parkinson's disease, meaning that the presence of this protein may not be sufficient to induce Parkinson's disease.
() Original source: Peipei Li 1, x, Bryan A. Killinger 1, 2, Elizabeth Ensink, et al. Gut Microbiota Dysbiosis Is Associated with Elevated Bile Acids in Parkinson's Disease, Metabolites (2021). DOI:10.3390/metabo11010029