Meta analysis of Tripterygium wilfordii extract in the treatment of rheumatoid arthritis
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Last Update: 2014-05-15
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Source: Internet
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Author: User
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Recently, researchers from the school of basic medicine of Nanjing University of traditional Chinese Medicine published a paper to evaluate the efficacy and safety of Tripterygium wilfordii extract (TwHF) in the treatment of rheumatoid arthritis (RA) It is pointed out that the efficacy and safety of TwHF in the treatment of RA need to be further verified by high quality and large sample RCT This article was published in the 10th issue of the Journal of modern integrated Chinese and Western medicine in 2014 Search PubMed, CBM, CNKI and other databases (as of June 2013), manually search relevant magazines and references, and select the documents that meet the standards According to Cochrane system evaluation method, the methodology quality evaluation included in the study was evaluated and the effective data was extracted, and meta analysis was carried out by Using Stata 10.0 software There were 15 RCTs included Compared with placebo, there were significant differences in the number of joint swelling, morning stiffness, hand grip strength and ESR (P < 0.05) The adverse reaction rate of TwHF was higher than that of placebo There was significant difference between TwHF and DMARDs in morning stiffness and hand grip strength (P < 0.05) There was no significant difference in adverse reaction rate There was a significant difference in joint swelling index between TwHF + DMARDs and DMARDs (P < 0.05), and no significant difference in adverse reaction rate.
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