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On June 15th, Merck (MSD) announced that its blockbuster PD-1 inhibitor pembrolizumab (trade name: Keytruda) has been approved by the China National Medical Products Administration (NMPA) for single-drug use KRAS, NRAS and BRAF genes are the first-line treatment for patients with wild-type, unresectable or metastatic high microsatellite instability (MSI-H) or mismatch repair gene defect (dMMR) colorectal cancer (CRC)
.
According to the press release, Pembrolizumab is currently the only single-drug PD-1 inhibitor approved for the first-line treatment of this type of MSI-H/dMMR advanced colorectal cancer in China
.
The approval of the new indication for pembrolizumab is based on data from the key global phase 3 clinical trial KEYNOTE-177
.
In this phase 3 clinical trial, pembrolizumab single-agent treatment of patients with MSI-H or dMMR unresectable or metastatic colorectal cancer can reduce the risk of disease progression or death by 40%, and the median progression-free survival It was 16.
