Men with late childbearing have a high probability of myopia

The scientific research team of Wenzhou Medical University, led by Yan Jia and Jin Zibing, recently announced that in the study of children with early hairstyles with high myopia (less environmental factors), a new early hairstyle with high myopia disease-causing gene BSG was found, and found that the probability of causing children with high myopia was positively corred with the reproductive age of the children's parents. The results have been published
and selected as the "Top 10 Advances in Chinese Pharmaceutical Biotechnology in 2017".
Jin Zibing, a professor at Wenzhou Medical University, said in an interview with Science and Technology Daily: "We have collected a large number of samples to come to the conclusion that both parents do not carry the gene of high myopia at all, if the father is over 35 years old at the time of childbirth, then their next generation will have an increase in the probability of high myopia, up to 50%." BSG's findings also raise a wake-up call for many late-marriage and late-birth men today. The
myopia is the main cause of blind population in our country at present. The study of its pathogenesis is difficult, and the intervention and prevention and control of high myopia are also facing many challenges. Wenzhou Medical University Eye Vision Hospital and the National Key Laboratory of Ophthalmology Optics and Vision Science, as the world's leading myopia research base, have long focused on myopia research. Yan Jia and Jin Zibing led the scientific research team to discover and clarify the new disease-causing gene BSG with high myopia through large samples, verify the pathogenicity of BSG mutation by expanding group screening and tapping the mutant gene into the mouse model, and construct a model of the genetic mutation mouse that can cause the eye axis to grow longer, and clarify the pathogenic mechanism.
study, BSG is expressed in the eyelashes and neuro-retina, suggesting that the root cause of this type of high myopia, the target tissue, lays a genetic foundation for the prevention and control of high myopia. This is the first myopia gene to be tested by a genetic mutation knocked into a mouse model, which has attracted international attention. The study also means that the pathogenesis and prevention and control of patients with high myopia in early hairstyles have entered a new era. (Source: Science and Technology Daily Li Wei)