Medicinal grade trichlorotert-butanol cas6001-64-5 use

Medicinal grade trichlorotert-butanol cas6001-64-5 use 【Content determination】 Determination by photovoltaic chromatography (general rule 0521
).

Chromatographic conditions and system suitability test Capillary column with polyethylene glycol (PEG-20M) (or similar polarity) as the fixation liquid is a column; The starting temperature is 35 ° C, maintained for 5 minutes, and warmed to 135 ° C at a rate of 20 ° C per minute for 10 minutes; The inlet temperature is 260°C; Detector temperature is 280°C; The shunt ratio is 10:1
.

The separation of the trichlorotert-butanol peak from the internal standard peak should be greater than 5
.

Preparation of internal standard solution Take an appropriate amount of 2,2,2-trichloroethanol, add n-hexane to dissolve and dilute to make a solution containing about 15mg per 1ml, that is, to obtain
.

Determination method Take about 100mg of this product, weigh it precisely, place it in a 10ml measuring flask, dissolve it with an internal standard solution and dilute to the scale, shake well, take 1μl, inject into the gas chromatograph, record the chromatography; Another trichlorotert-butanol control is about 100mg, precision weighing, dissolved with internal standard solution and diluted to the scale, shake well, the same method of determination, according to the internal standard method to calculate the peak area, that is, obtained
.

Colorless crystals
.

It is composed
of two kinds of crystals: semi-molecular crystalline water type and anhydrous type.

It contains semi-molecular crystalline water type with melting point of 78 °C, slightly soluble in water (1:250), soluble in ethanol (1:1), glycerin (1:10), ethyl, chloroform and volatile oils
.

The anhydrous type has a melting point of 97 °C, a boiling point of 167 °C, and a boiling point of 135 °C (32.
7 kPa
).

Soluble in hot water, 1g can be soluble in 1ml ethanol or 10ml glycerin, soluble in ethyl, petroleum ether, acetone, chloroform, glacial acetic acid, oil
.

It is easy to sublimate when heated and can volatilize
with water vapor.

Camphor-like smell
.

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