mBio: A new target for infectious disease immunotherapy.

, June 27, 2020 /PRNewswire/ -- BioValley BIOON/--- Researchers and colleagues at the National Institutes of Health found that when the immune system first responds to infectious agents such as viruses or bacteria, natural braking prevents overactivationTheir new study, published in the journal mBio, describes the fundamentals of this braking mechanism and how SARS-CoV-2 is activatedTheir findings provide a potential target for immunotherapy(photo source:when cells identify infectious origins with PAMP molecular characteristics, it increases the expression of CD47 molecules on the cell surface, the signal of "don't eat me." Increased expression of CD47 weakens the ability of macrophagesThe phagocytosis cells are swallowed by infected cells and explained will further stimulate the immune responseObservations found that THE increase in CD47 was affected by a variety of types of infections, including infections caused by mouse retroviruses, lymphocyte vasculature meningitis virus, LaCrosse virus, SARS CoV-2, and salmonella with Boshoheliospiration and typhoidthe authors demonstrated that they can increase the speed at which pathogens are removed by transvirus-mediated mouse models that block CD47-mediated signals with antibodiesIn addition, the CD47 gene in mice was removed to improve its ability to control mycobacterium tuberculosis infection and significantly prolong its survivalIn addition, retrospective studies of cells and plasma in people infected with the hepatitis C virus have shown that there is also an increase in CD47 in the human bodyIn these studies, inflammatory cytokine stimulation and direct infection both contributed to an increase in CD47 expression(Bio Valley Bioon.com)source:Discovery A project for the original origin of theof the:Tal, M.C., et al (2020) Upregulation of CD47 Is a Checkpoint A Host Response to Recognition.
mBio
doi.org/10.1128/mBio.01293-20.
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