Major medical team makes breakthrough in new coronavirus T-cell immunity research

17, the reporter learned from Chongqing Medical University, Research Center, Professor Jin Yishun school immunization team in the school novel coronavirus (SARS-CoV-2 ) emergency projects in research, in the study of specific T lymphocytes has made a breakthroughThis breakthrough lays the foundation for further follow-up research and development of new vaccines and crown T cell immunotherapy pneumoniaIt is understood that since the project started research team in Yongchuan Affiliated Hospital of Infectious Diseases and the strong support of the Third Affiliated Hospital of collection and treatment and other new crown peripheral blood samples of patients recovering from pneumonia developed for the rapid screening of potential and of fully human monoclonal antibody technology, and successfully obtained a new crown virus and has a high affinity fully human and vitality of the many strains of monoclonal antibodies, and lay the foundation for the antibody drug developmentFollowing this breakthrough research, the team once again achieve breakthrough results in research-specific T cell immune crown new virusesfor the team to cover more than 70% of the Chinese population genotype HLA-A2, HLA-A24 and HLA-A11 and so on, to carry out the new crown patients recovering from pneumonia in peripheral blood lymphocyte antigen-specific T lymphocytes screening of peptide and T cell receptor (TCR), the various genotypes successful diversification of the antigen peptide, a peptide comprising the new crown viral antigen S protein receptor binding region (the RBD) of these new viruses crown T-cell receptor binding antigenic peptides has not yet been reportedXinguan virus enters the body infected host cells and replication in cellsNeutralizing antibodies are only responsible for viral clearance or prevent viral infection of host cell function outside the cell, because they can not enter the cell and the inability of the parasite inside the cell the virusThe wisdom of the human immune system T lymphocyte gives clear the virus in cell capacityTherefore, the final clear the virus in the infected organ cells require T cell immune response involving cellsThe new crown virus-specific T cells may help patients or infected completely rid of the virus, to achieve the purpose of cureFor asymptomatic infection in patients with immune therapy and complex positive T cells is one of the ways effective cureIn this study, the new crown pneumonia T cell immunotherapy method providedT cell antigen epitope peptide antibodies obtained will be the best source of material vaccine research and development, provide the foundation for the study of a new Task Force follow-crown vaccine research and developmentAccording to reports, the team led by Jin Yishun create a series of new crown virus neutralizing antibody drug development and specific T cell receptor (TCR) and antigen peptide screening and other related technologies, is expected to crown the new virus prevention and provide effective treatment strategies(A BiovalleyBioon.com)