Main efficacy and function of pharmaceutical grade sorbic acid

Main functions and effects of pharmaceutical grade sorbic acid ShanlisuanSorbic Acid C6H8O2 112.
13 [22500-92-1] This product is (E, E)-2,4-hexadienoic acid
.

Calculated by anhydrous, the content of C6H8O2 shall not be less than 99.
0%
.

【Properties】 This product is a white to slightly yellowish white crystalline powder; it has a special odor
.

This product is easily soluble in ethanol, soluble in medium, and very slightly soluble in water
.

Melting point The melting point of this product (general rule 0612) is 132～136℃
.

【Identification】 (1) Take about 0.
2g of this product, add 2ml of ethanol to dissolve it, add a few drops of bromine test solution, and the color of bromine will fade
.

(2) Take this product, add 0.
1mol/L hydrochloric acid solution to dissolve and dilute it to make a solution containing about 2.
5μg per 1ml, and measure it according to UV-Vis spectrophotometry (general rule 0401), it has the maximum absorption at the wavelength of 264nm
.

　　(3) The infrared absorption spectrum of this product should be consistent with the control spectrum (spectrum set 25)
.

　　【Check】Clarity and color of ethanol solution Take 1.
0g of this product, add 50ml of ethanol to dissolve, and check according to the law (general rules 0901 and 0902), the solution should be clear and colorless
.

　　Aldehyde take 1.
0g of this product, add 30ml of water and 50ml of isopropanol to dissolve, adjust the pH value to 4.
0 with 0.
1mol/L sodium hydroxide solution, add water to dilute to 100ml, shake well, take 10ml, add colorless fuchsin solution ( Take 0.
1g of basic fuchsin, add 60ml of water, add 10ml of 10% anhydrous sodium sulfite solution, shake well, add 2ml of hydrochloric acid dropwise while stirring, add water to 100ml and place in the dark for more than 12 hours, add 0.
2-0.
3g of activated carbon, shake , filter and get it
.

If the solution is turbid, it needs to be filtered before use; if the test solution is violet, add activated carbon to decolorize it again) 1ml, shake well, and leave it for 30 minutes.
Dilute to the mark, shake well, take an appropriate amount, dilute with n-propanol to make a solution containing 0.
1mg of acetaldehyde per 1ml, take 1.
5ml of this solution, add 4.
5ml of water and 4ml of isopropanol, shake well, add colorless Magenta solution 1ml, shake well), must not be darker (0.
15%)
.

　　Take this product for moisture and measure it according to the moisture determination method (General Rule 0832 First Method 1), and the moisture content should not exceed 0.
5%
.

　　Take 1.
0g of this product for the residue on ignition and inspect it according to the law (General Rule 0841), and the remaining residue should not exceed 0.
1%
.

　　Heavy metals and residues left under residue on ignition shall be inspected in accordance with the law (the second method of General Rule 0821), and the heavy metals shall not exceed 10 parts per million
.

　　[Determination of content] Take about 0.
25g of this product, accurately weigh it, add 25ml of neutral ethanol (neutral to phenolphthalein indicator solution) to dissolve, add a few drops of phenolphthalein indicator solution, and use sodium hydroxide titration solution (0.
1mol/L) ) titration
.

Each 1ml of sodium hydroxide titration solution (0.
1mol/L) is equivalent to 11.
21mg of C6H8O2
.

　　【Category】 Medicinal excipients, bacteriostatic agents
.

　　【Storage】 shading, sealed and stored in a cool place
.