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Magnesium Aluminum Silicate as a pharmaceutical excipient has been widely used in developed countries in the world
.
It can be obtained from silicate ore containing montmorillonite, which has a higher magnesium content.
Magnesium aluminum silicate has been used in tablets, ointments and creams for many years
.
It is used alone or in combination with other suspending agents as a suspending agent or stabilizer in oral or external preparations.
After its aqueous dispersionis mixed with other suspending agents such as xanthan gum , the viscosity increases significantly due to the synergistic effect
use | concentration% |
Adsorbent | 10~50 |
Adhesive | 2~10 |
Disintegrant | 2~10 |
Emulsifier stabilizer (oral) | 1~5 |
Emulsifier stabilizer (topical) | 2~5 |
Suspending agent (oral) | 0. |
Suspending agent (topical) | 1~10 |
stabilizer | 0. |
Viscosity modifier | 2~10 |
Magnesium aluminum silicate has the following characteristics:
1.
Stability: This product has a three-dimensional spatial network structure and a large yield value, and is not affected by temperature.
Therefore, it is suitable for oil-in-water emulsions (O/W) and water-in-oil emulsions (W/O).
The most effective stabilizer
.
It is the most effective stabilizer even for suspensions containing high-density substances such as minerals, salts and organic matter
2.
Rheology: Magnesium aluminum silicate has high viscosity and thixotropy.
3.
Cation exchange: The cations between the crystal lattices of this product can exchange reaction with other positively charged ions, and the cation exchange capacity is 81.
6meq/100g
.
4.
Anti-enzyme ability: Under the action of cellulase, the viscosity of this product is basically unchanged or even increased, indicating that the anti-enzyme ability is very strong
.
5.
Acid and alkali resistance: This product is very stable in a large pH range
.
6.
Anti-degradation: This product is a mineral and will not be decomposed by bacteria, heating or excessive mechanical shearing
.
7.
Thickening effect: When this product is used in conjunction with an appropriate amount of CMC, the viscosity can be significantly increased, showing an obvious synergistic thickening effect
.
8.
Salt solubility: This product has a good compatibility with dielectrics, and the viscosity of the system remains basically unchanged.
When the amount of inorganic salt dielectric reaches a certain value (1%), its viscosity will increase exponentially
.
Magnesium aluminum silicate is composed of thousands of tiny pieces.
When magnesium aluminum silicate is mixed with water, the latter penetrates the area between the pieces, forcing the pieces to separate further, and exchangeable ions begin to diffuse away from the surface of the pieces.
Come
.
According to the principle of permeation, water molecules further penetrate between the small pieces until the small pieces are completely separated
Based on the above-mentioned excellent physical and chemical properties, magnesium aluminum silicate is widely used in the manufacture of various dosage forms of drugs, such as:
1.
Large swelling in water, and peculiar thixotropic and suspending properties, stable water-in-oil emulsions, oil-in-water emulsions and suspensions, and can be used in various medicinal ointments (pastes and ointments), liniments, and pastes , Emulsions, suppositories, suspensions and other pharmaceutical manufacturing
.
2.
Good cohesiveness, stability and disintegration.
It can be used in the processing of various tablets, pills and granular medicines.
The processed medicines have smooth and uniform appearance, rapid disintegration, and small and uniform disintegration particles
.
3.
Ideal film-forming strength and cohesiveness, a large number of film-forming materials used for film agents, and coating materials for capsules
.
4.
Excellent suspension, colloidal stability, thixotropy, non-toxic and non-irritating, and can be used in the manufacture of various oral liquid drugs
.
5.
With colloidal stability, suspension and thixotropy, it can be used as suspending agent, emulsion and emulsifier stabilizer, binder, excipient, filter agent of various drugs
.
6.
It has good ion exchange and adsorption properties, and can be used as a variety of drug carriers, so that the effective components of the drug can achieve the purpose of slow and controlled release
.
7.
As the matrix material of hydroquinone, this product can obviously delay the discoloration of hydroquinone.
It can also be used as a decolorizing agent, capsule and flavoring agent for Chinese herbal medicine
.
Compatibility taboo!
Magnesium aluminum silicate is not suitable to exist in acidic solutions with a pH lower than 3.
5 due to its extremely low inertness and contraindications
.
Magnesium aluminum silicate, like other clays, can adsorb drugs.
American Colloid Company (AMERICAN COLLOID COMPANY) is one of the world's leading producers of bentonite clay.
American Colloid Company, Health & Beauty Solutions, Inc.
, and Specialty Minerals Inc.
are all affiliated with the American MTI (Minerals Technologies) group
.
The unique chemical structure of bentonite gives it multiple functions, enabling it to be used as a thickener, sealant, adhesive, lubricant or absorbent
.
Magnesium aluminum silicate Magnabrite produced by ACC ? Magnesium Aluminum Silicate, USP/NF
*Some cases of using Magnesium Aluminum Silicate Magnabrite in formulations that have been marketed in the U.
