Lymphoma cell metabolism may provide new tumor targets

According to a study by researchers at Weill Cornell School of Medicine and Cornell University’s Ithaca campus, aggressive and relatively common lymphomas called diffuse large B-cell lymphomas (DLBCLs) have critical metabolic fragility Sex can be used to trick these cancers into starving oneself

The researchers’ research was published in the December 13th issue of Blood Cancer Discovery.

"ATF4 represents a crucial and exploitable weakness in dlbcl, and regardless of the specific genetic mutation that triggers them, they all seem to have this weakness

Dr.

Lymphoma is a type of blood cancer that usually originates from immune cells, such as B cells that produce antibodies

Melnick, Dr.

In this new study, the researchers further explored how SIRT3 promotes the growth of DLBCL, and found that one of the important ways is to increase the production of another protein that affects metabolism, ATF4

Their experiments show that while SIRT3 accelerates the metabolism of DLBCL, it also reduces the amino acid pool that cells use to make proteins and promote their growth

Dr.

To further take advantage of this effect for treatment, the researchers tested a compound that can block the activation of ATF4 and found that it has a similar broad effect on DLBCL cells

"An interesting thing about this study is that it shows how nutritional conditions, in principle, from a patient's diet, can profoundly affect cancer cell activity," said the first author of the study by Dr.

The team is currently conducting further experiments to find the best way to target the SIRT3-ATF4 axis to treat dlbcl

"My laboratory has been studying the sirtuin family of enzymes for more than 10 years, but this research reveals some very interesting links between SIRT3, metabolism, and nutrition or stress perception," said Dr.