-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
On September 10, 2021, Luo Shujin's group from the School of Life Sciences, Peking University, State Key Laboratory of Protein and Plant Genetic Research, Peking University-Tsinghua Life Sciences Joint Center, and Zou Zhengting's group from the Institute of Zoology, Chinese Academy of Sciences jointly published a paper on PLoS Genetics .
Genomic and transcriptome analysis identified the gene SLC2A11B, which determines the diversity of pigeons' eye color.
The loss-of-function mutation causes the lack of yellow iris to form white eyes, and has been artificially selected for a long time during the domestication of pigeons
.
SLC2A11B is related to the blue or brown-black eyes of some birds.
The rich fur color/skin phenotype of vertebrates plays an important role in camouflage, sexual selection, inter-individual communication, and body temperature regulation.
The pigment color is mainly determined by three types of pigment cells: yellow/red pigment, iridescent/white pigment, and melanocytes.
Based on the whole genome sequencing and whole genome association analysis (GWAS) of 92 domestic pigeons, this study identified the pigeon white eye trait determining gene as the SLC2A11B nonsense mutation W49X
.
SLC2A11B encodes a 12 transmembrane region transporter, whose mutation is known to affect the development and differentiation of fish yellow pigment cells
Based on the comparison and function prediction of the published bird SLC2A11B protein sequence, non-synonymous mutations affecting normal function were found in 6 birds lacking yellow pigment in the iris (eye color is blue or brown-black), which proves that SLC2A11B has a positive effect on yellow The possible conservative functions of eye traits and their role in the formation of bird eye color diversity
.
Further analysis of the homologous gene evolution of vertebrates of 41 species including birds, alligators, turtles, snakes, lizards, and fishes showed that SLC2A11B experienced significant relaxation in birds, supporting the evolution of birds from non-avian dinosaur ancestors In the process, the hypothesis that being covered by feathers makes the skin color functionally redundant, and is no longer subject to natural selection pressure, leading to the death of pigment cells in the dermis of birds.
Associate researcher Si Si and Associate Researcher Xu Xiao from the 2016-level Ph.
D.
candidate of the Joint Center for Life Sciences of Luo Shujin's Research Group are the co-first authors of this article
.
Researcher Luo Shujin, associate researcher Xu Xiao, and researcher Zou Zhengting from Institute of Zoology, Chinese Academy of Sciences are the co-corresponding authors
Original link:
https://journals.
Si S, Xu X, Zhuang Y, Gao X, Zhang H, Zou Z, Luo SJ.
Genomic analysis revealed that the SLC2A11B loss-of-function mutation determines the white eye traits of domestic pigeons and is related to the diversity of bird eye color
