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On September 5, 2022, The Plant Journal published the latest research results
Benzyl isoquinoline alkaloids in plants, such as morphine, berberine, blood root base, etc.
The study identified eight benzyl isoquinoline alkaloids from three tissues (roots, bark and leaves) of Chinese Goosefoot and hybrid Goosefoot cataloids, and the content of these alkaloids was detected
(Identification of benzyl isoquinoline components of Thrushalapina and Calamology of Expression of Candidate Methyltransferase)
Further enzymatic activity studies identified specific catalytic (S)-coclaurine C6 locations and C7 positions of oxymethyltransferase LcOMT1 and LcOMT3, and catalytic (S)-coclaurine azomethyltransferase LcNMT1
Finally, phylogenetic analysis showed that the number of benzyl isoquinoline as a more primitive species was smaller and the substrate specificity was narrower than that of Ranunculin, which showed that the expansion of nitrogenyl isoquinoline in angiosperms made an important contribution
(In vitro reaction identification of the catalytic function of LcOMT1/LcOMT3/LcNMT1)
The School of Pharmacy of Wuhan University and the Institute of Pharmacy of Zhongnan Hospital are the first, Cheng Weijia, a doctoral student in the class of 2021, is the first author, and researcher Lu Li is the corresponding author of
Paper Link: https://onlinelibrary.
