Lock anti-AIDS amino acids, enveloping circles are shrinking

On January 3,, the reporter interviewed at Nanjing University Medical School PublicHealthMedical Center was informed that the university's Professor Wu Zhiwei's team made new progress in the study of anti-HIV (HIV) protein: they have analyzed and identified specific functional units with the active protein GP-340, which contains 16 amino acids and inhibits HIV infectionWu Zhiwei told reporters that this means that once the "minimum, necessary number of amino acids" is finalized, researchers can design aids prevention drugsIn the 1980s and 1990s, epidemiological analysis found that the risk of HIV transmitting through oral saliva was extremely low or largely uncommonAlthough researchers can detect HIV genes in the saliva of AIDS patients, the virus isolated from there cannot infect other cellsThis phenomenon caused a number of AIDS experts, including Professor Wu Zhiwei bold guess: the mouth must contain some anti-viral ingredients!Wu Zhiwei after the study of saliva composition found that the mouth generally does not have live viruses, because saliva contains several active proteins that can fight HIV infection, especially a protein called gp-340The gene of this protein may play two more important roles in the human body: one is related to cell development and differentiation, and second, it is related to the human's natural immunity, which is consistent with the activity of the gp-340 protein that prevents HIV-infected cellsWu Zhiwei told reporters that protein can be composed of hundreds of amino acids, but the real interaction with the virus to prevent the virus from invading the cells may be then seven or eight amino acidsThey are working with New York University on a "shrink-close ring" study to find specific functional unitsAt the beginning of 2007, Wu Zhiwei's team narrowed the specific functional units of active proteins with anti-HIV infection to one-tenth of the original protein, and found that 16 of the 107 amino acids locked in the locked up may play a more important role in suppressing HIV infection(Zhang Wei Luojing)