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Liver Cancer: Patients with advanced liver cancer with vascular tumor thrombi may choose hepatic artery infusion chemotherapy + radiotherapy!

 Last Update: 2021-05-21
 Source: Internet
 Author: User

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Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide, and the prognosis of unresectable HCC is extremely poor.

Patients with advanced HCC with non-alcoholic fatty liver diabetes mellitus combined with portal vein trunk or two-lobe tumor thrombosis (Vp4) have worse overall survival time with thrombosis

This study aims to clarify the prognosis of hepatic arterial infusion chemotherapy (HAIC) combined with radiotherapy (RT) in patients with advanced liver cancer combined with Vp4, and analyze the factors that affect the prognosis.

This is a retrospective cohort study that recruited 51 HCC patients who were treated with HAIC and RT due to portal vein tumor thrombosis.

Overall survival and progression-free survival

Overall, the median overall survival and median progression-free survival of patients in the study cohort were 12.

The median overall survival and median progression-free survival are 12.

The influence of tumor volume and extrahepatic metastasis on prognosis

Multivariate analysis showed that the relative volume of the liver by tumor >50% (HR 3.

The relative volume of the tumor in the liver>50% (HR 3.

Adverse events

Patients with advanced HCC combined with Vp4 did not develop liver failure after receiving HAIC combined with RT treatment.

The safety and tolerability of the combination therapy of HAIC and RT are good

In summary, HAIC combined with radiotherapy may be a better option for the treatment of advanced liver cancer with Vp4 .

HAIC combined with radiotherapy may be a better plan for the treatment of advanced liver cancer with Vp4 HAIC combined with radiotherapy may be a better plan for the treatment of advanced liver cancer with Vp4

Original source:

Kosaka Yumi, Kimura Tomoki, Kawaoka Tomokazu et al.

org/10.
1159/000513706" target="_blank" rel="noopener">Hepatic Arterial Infusion Chemotherapy Combined with Radiation Therapy for Advanced Hepatocellular Carcinoma with Tumor Thrombosis of the Main Trunk or Bilobar of the Portal Vein in this message

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