-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
On August 31, Science China Life Sciences published online the latest research results of Liu Xingguo’s team at the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, "Short-form OPA1 is a molecular chaperone in mitochondrial intermembrane space" The research paper reported that in the double-membrane organelle of mitochondria, the membrane space between the inner and outer membranes is the worst stress region from multiple damage to the respiratory chain, and the soluble short-chain protein of OPA1 acts as a molecular chaperone in this region.
(Molecular chaperon) This new function of helping protein folding plays an important role in maintaining mitochondrial homeostasis
.
Mitochondria are important organelles in eukaryotic cells.
How to regulate the nucleus of mitochondria has always been a basic scientific question that needs to be answered urgently
.
Dr.
Liu Xingguo’s team discovered that the mitochondrial inner membrane fusion protein OPA1, a soluble short-chain protein (S-OPA1) sheared in the interstitial space under stress, acts as a molecular chaperone in the interstitial space and is used to maintain protein homeostasis in the interstitial space
.
Firstly, the soluble short-chain form of S-OPA1 protein was purified in vitro, showing that it protects the substrate protein from heat and chemically induced aggregation, and improves the resistance of bacteria to heat stimuli
Mitochondria have a relatively high temperature in the cell, about 10°C higher than the surrounding environment, and the membrane gap is the area with the worst conditions of high temperature, oxidation, and PH stress
.
Compared with other cell regions, the heat shock protein family used to help protein folding, such as Hsp60 and Hsp70, has not been identified in the mitochondrial membrane space
OPA1 (Optic Atrophy 1, Optic Atrophy 1) plays an important role in a variety of physiology and pathology.
Dr.
Xingguo Liu has systematically studied the anti-stress effect of OPA1 in mitochondria.
This continuous work has enabled people to treat OPA1 in mitochondrial damage.
There is a new and comprehensive understanding of the multiple roles of "three heads and six arms": First, when mitochondria are under stress, the soluble short-chain protein S-OPA1 in the interstitial membrane acts as a molecular chaperone to play the role of "benevolence and righteousness" to maintain mitochondria.
Protein homeostasis; secondly, when mitochondria get foreign aid through social interaction and their function is restored, OPA1's spliceosome without exon 4b plays a decisive role in "emotional intelligence" and can "kiss-and-run" with other mitochondria with normal functions.
Or complete fusion is restored (Liu X et al.
, 2019, EMBO J); again, when the mitochondrial self-function is restored, the OPA1 spliceosome with exon 4b plays a "conscience" initiation function, specifically binding to the transcription of mitochondrial DNA (Liu X*, 2020, Front Cell Dev Biol); finally, when the mitochondria is severely damaged, it will cause cell death, OPA1 suddenly "heart breaks" and releases the cytochrome c of the inner crest to cause apoptosis (Liu X *, 2015, Heptology)
.
This research was supported by the national key research and development projects, the Chinese Academy of Sciences, the National Natural Science Foundation of China, Guangdong Province and Guangzhou City
.
Paper link
Multiple functions of OPA1 in mitochondria
