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Liu Wenxian's group published a paper in CMI, revealing the important mechanism of Myc inhibitor exerting new functions in anti-tumor immune response

 Last Update: 2022-08-19
 Source: Internet
 Author: User

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On August 12, Liu Wenxian's group published a research paper entitled Myc inhibition tips the immune balance to promote antitumor immunity in the immunology journal "Cellular & Molecular Immunology.

Myc, as the most famous proto-oncogene, has always been the focus of researc.

After treating tumor-bearing mice with Myc inhibitor Mycro3, researchers found that regulatory T cells (Treg) in the tumor microenvironment were significantly decreased, CD8 ⁺ T cells were significantly increased, and tumor growth was slo.

This study focused on the function of the proto-oncogene Myc in anti-tumor immune responses, and demonstrated for the first time that the sensitivity of different T cell subsets to Myc inhibitors in the tumor microenvironment is determined by the expression of Myc protei.

Doctoral students Yang Chao and Liu Yun from the School of Life Sciences of Xiamen University and Hu Yudi, a master student from the School of Medicine, are the co-first authors of the pape.

Full text link: https://do.

(Photo/Wen Liu Wenxian's research group)

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