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On July 28, Liu Bo's research group published a research paper
entitled A dRASSF-STRIPAK-Imd-JAK/STAT axis controls antiviral response in Drosophila in Cell Reports.
Viruses pose a serious threat to global public health, and studying host antiviral immune mechanisms is critical
to designing new antiviral strategies.
Conserved members of the RASSF protein family are important tumor suppressors
.
The researchers first found that dRassf mutant flies were unusually sensitive to viral infections, suggesting that the gene was involved in the antiviral immune response
.
This study discovered the importance of the tumor suppressor dRASSF in antiviral innate immunity, revealed a new interaction mechanism between the Imd signaling pathway and the JAK/STAT signaling pathway, and confirmed the key of balanced JAK/STAT signaling pathway activity for antiviral immunity in Drosophila
。 This study elucidated for the first time the important role of the dRASSF-STRIPAK-IMD-JAK/STAT signaling axis in the antiviral immune response of Drosophila, enriched the antiviral innate immunity signaling network of Drosophila, and was of great guiding significance for further exploration of
the role of RASSF family proteins in mammalian antiviral immunity in the future.
Shen Rui and Zheng Kewei, doctoral students in Liu Bo's research group, are the co-first authors of
this paper.
