 Home > Active Ingredient News > Antitumor Therapy > Lin Aifu Research Group: Iron metabolism, iron death and long non-coding RNAs in cancer: known and unknown

Lin Aifu Research Group: Iron metabolism, iron death and long non-coding RNAs in cancer: known and unknown

 Last Update: 2022-11-15
 Source: Internet
 Author: User

Tags

iron chelating drugs

long life

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Content introduction

Chinese Summary:

Outline:

Metabolic reprogramming is one of the hallmark events of tumors, through which cancer cells meet their own energy supply and unlimited proliferation
.
As one of the essential trace elements for life, iron is essential
for a variety of biological processes including DNA synthesis and repair, cellular respiration, oxygen transport, lipid oxidation, signal transduction and other processes.
Studies have shown that cancer cells increase intracellular iron ion concentrations to promote cell proliferation
through a variety of mechanisms.
Iron death, a form of cell death caused by iron-catalyzed peroxidation of polyunsaturated fatty acids, is a potential therapeutic target for the treatment of drug-resistant tumors
.
As a novel regulatory element, long non-coding RNA (lncRNA) is involved in regulating various cellular processes
such as cell metabolism, proliferation, apoptosis, and iron death.
In this review, we summarised the relationship between
iron metabolism, iron death, and lncRNA in tumorigenesis.
An in-depth discussion of the role of lncRNA in tumor iron death will provide new strategies and perspectives
for jointly targeting lncRNA and iron death-related molecules in tumor treatment.

Keyword groups:

Iron metabolism; iron death; long noncoding RNA (lncRNA); Tumorigenesis

Author:

Lei QU, Xinyu HE, Qian TANG, Xiao FAN, Jian LIU, Aifu LIN

Citation format of this article:

Lei QU, Xinyu HE, Qian TANG, Xiao FAN, Jian LIU, Aifu LIN.
Ironmetabolism, ferroptosis, and lncRNA in cancer: knowns and unknowns[J].
Journalof Zhejiang University Science B, 2022, 23(10): 844-862.

https://doi.
org/10.
1631/jzus.
B2200194

Essential introduction to this article:

Full text download address: https://jzus.
zju.
edu.
cn/oldversion/opentxt.
php?doi=10.
1631/jzus.
B2200194

About this journal

Journal of Zhejiang University (English Edition) Series B: Biomedicine and Biotechnology, referred to as JZUS-B, is a comprehensive English monthly journal
of biology.
JZUS-B has been included in SCI-E since 2008, with a latest impact factor of 5.
552, and has been searched
by well-known domestic and foreign platforms such as MEDLINE/PubMed, PMC, Scopus, BA, BIOSIS Previews, etc.

JZUS-B receives articles in life sciences, medicine, pharmacy, biochemistry, biotechnology and bioengineering, agronomy, ecology, and zoology
.
Article types include Review, Article, Perspective, Viewpoint, Editorial, Correspondence, etc
.

The journal has always implemented a strict international peer review mechanism, with an average review period of 42 days and an average acceptance time of 53 days
.
After acceptance, the article will be immediately online in Press and will generally be officially published
within 2 months.

"Content-oriented, flexible form" is the characteristic of
this journal.
JZUS-B welcomes outstanding scholars at home and abroad to submit the latest scientific research achievements, controversial topics, review papers and organize the publication of hot albums
.

Journal Springer homepage:

style="min-height: 14px;outline: 0px;max-width: 536px;box-sizing: border-box;overflow-wrap: break-word !important;" _msthash="251726" _msttexthash="586040">Online Submission Address:

style="outline: 0px;max-width: 100%;box-sizing: border-box !important;overflow-wrap: break-word !important;">

Zhejiang University Journal English version is a number of English academic journals of the general name, the scope of collection covers all directions of science, engineering, agriculture and medicine, welcome to submit to our journal, you can pay attention to our journal public number zdxbywb for more information
.

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.