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Recently, the top international pharmacology journal Pharmacology & Therapeutics published an article entitled " The new fate of internalized membrane receptors: Internalized activation " from the research group of Professor Li Zijian of Peking University Third Hospital online in full
.
Article screenshot
Cell membrane receptors are involved in almost all life activities, and their dysfunction is the main mechanism leading to major diseases including cardiovascular diseases, tumors, metabolic diseases and neurodegenerative diseases
.
Therefore, receptors are the most important drug targets, and more than 50% of drugs use receptors as their targets
The traditional view is that the cell membrane receptors have two fates after being endocytosed into the cell, namely degradation and recycling
.
Based on the latest research and systematic theoretical results of Li Zijian’s research group on receptor signal transduction mechanisms over the years, combined with the cutting-edge findings of international colleagues, Li Zijian’s research group proposed the third fate of cell membrane receptor endocytosis, "endocytosis activation"
This article not only systematically discusses the initiation of endocytosis activation, endocytosis pathways, subcellular organelle location and signal activation process, but also gives the membrane receptors the significance of signal transduction after endocytosis: 1.
Cell membrane receptors die after endocytosis.
Changes in the fate of life; 2.
The role of membrane receptors from receptors to effectors; 3.
The temporal and spatial diversity, functional diversity, and maintenance of cell homeostasis of membrane receptors
.
In addition, the article also explained in depth the importance of endocytosis activation in diseases
The new fate of membrane receptor endocytosis: endocytosis activation
.
The two classic fates of membrane receptor endocytosis are receptor recycling and receptor degradation.
This article follows Li Zijian’s group’s invitation to propose the concept of receptor "endocytosis activation" in the Cell sub-Journal Trends in Cell Biology in April 2021 (Wenjing Wang, Jingwei Bian, Zijian Li, Internalized Activation of Membrane Receptors: From Phenomenon to Theory .
Trends in Cell Biology , 2021 Jun;31(6):428-431.
), further deepen and expand the theory of receptor endocytosis
.
In addition, Li Zijian’s group was invited to participate in the Cell sub-Journal Trends in Pharmacological Sciences (Wenjing Wang, Yunhui Qiao, Zijian Li.
Dr.
Wang Wenjing and Bian Jingwei from Peking University Third Hospital are the co-first authors of the article, and Li Zijian is the corresponding author
.
This achievement was funded by the National Natural Science Foundation of China's Major Research Program Integration Project (91939301) and the National Natural Science Foundation of China's Key International Cooperation and Exchange Project (81820108031)
