Li Lanjuan's team: The mitochondrial mechanism of necrotizing apoptosis in liver disease

Paper Title: Mitochondrial Mechanisms of Necroptosis in Liver Diseases (Mitochondrial Mechanisms of Necroptosis in Liver Diseases)

Journal: IJMS

Authors: Chen Xue, Xinyu Gu, Ganglei Li, Zhengyi Bao and Lanjuan Li

Posting time: 23 December 2020

DOI: 10.

WeChat link:

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Journal link:

https:// href="https://" target="_blank">https:// style="color:#0000ff;"> https:// style="text-indent:2em"> Liver diseases, including hepatitis B, hepatitis C, non-alcoholic and alcoholic steatohepatitis and related liver diseases such as liver fibrosis, cirrhosis, liver failure and hepatocellular carcinoma, are one of the main causes of disease and death in the world .

Image source: Pixabay

Mitochondria regulate cell necroptosis

Necroptosis is a common and controllable form of programmed cell necrosis in the liver.

Although the specific mechanism of the necrosome complex inducing cell necroptosis is still unclear, some studies have shown that the generation of ROS is closely related to cell necroptosis.

Figure 1.

Figure 2.

Mitochondrial dysfunction is related to acute liver injury.

Subsequently, the author discussed the mechanism of mitochondrial necroptosis in chronic liver disease.

Analysis conclusion

In various liver diseases, mitochondria are multi-faceted regulators of the necrotizing apoptotic pathway, which play multiple functions such as promoting inflammation, enhancing immune response and regulating disease progression.

Research Outlook

Mitochondria play an important regulatory role in cell necrotic apoptosis, which implies that the prevention and treatment of liver disease by targeting to inhibit the apoptosis/necrosis pathway induced by mitochondria has great prospects.

Journal Introduction

International Journal of Molecular Sciences (IJMS) (ISSN 1422-0067; IF 4.