Leukemia break! New method highly specific ally and efficient elimination of leukemia stem cells!

2020 May 15 News /BioValleyBIOON / -hematopoietic stem cells from healthy donors can help with acuteleukemia patientsHowever, the side effects of treatment are often severeA group of researchers led by the University of Zurich now show the hematopoietic stem cellshowmore selectively cleared by a healthy immune therapy instead of chemotherapy in mice and cancerThe researchers hope the purpose of testing new immune therapies in humans as soon as possibleacute myeloid leukemia (AML) is an aggressive cancer is a blood forming systemIt affects a variety of leukocytes, erythrocytes and plateletshematopoietic stem cells or blood stem cellsLeukemia stem cells multiply rapidly, proliferation in the bone marrow and blood, and can attack other organsPatients usually receive intensive chemotherapy and sometimes radiotherapyAfter that, they need from a healthy donor hematopoietic stem cells in a This therapy has serious side effects, and therefore not suitable for many patients a Source: iStockwildpixel selectively remove a leukemia and hematopoietic stem cells from a University of Zurich (UZH), a group of scientists University Hospital of Zurich (USZ) and ETH Zurich and doctors have now successfully in animal models more selectively eliminating leukemia and hematopoietic stem cells Chemotherapy and radiotherapy not only to destroy cancer cells and hematopoietic stem cells a , and will affect all dividing cells Almost all organizations are affected "Compared with conventional tactics, our method is very selective, which means that mature blood cells and other tissues survived," said study leader MarkusManz, a professor of medicine at the University of UZH, also tumor USZ University Director and hematology researchers used a novel cell therapy is called CAR-T This therapy using genetically modified, so that human immune cells have one receptor, to enable them to systematically healthy cells and hematopoietic stem cells and destroy them with binding of leukemic stem This creates room for new transplant donor cells To avoid transgenic immune cells also attack from the donor hematopoietic stem cells, CAR-T cells after the completion of their work and inactivated prior to transplantation This is accomplished by using an antibody against CAR-T cell surface markers to achieve After the donor Stem cell transplantation, they occupy a position in the bone marrow, hematopoietic and immune systems begin to rebuild plan selective immune-mediated elimination clinical results obtained in the laboratory and there are human cancer cells and the blood of mice But MarkusManz believe this therapy will work in humans: "The principle is this: In a living organism, it is possible with high accuracy and eliminate leukemia stem cells." Researchers are now testing whether this method is only applicable to CAR-T cells, or also to a simpler structure, such as T cell activating antibodies Once the pre-clinical work is completed, Manz want to test this new immunotherapy in human clinical studies Manz explains: "If our method is also applicable to humans, it may replace chemotherapy have serious side effects, which will have a large patient suffering from acute myeloid leukemia or other blood Stem cell disease beneficial "(bio Valley Bioon.com) reference:. Moreselectiveeliminationofleukemiastemcellsandbloodstemcells RenierMyburghetal Anti-humanCD117CART-cellsefficientlyeliminatehealthyandmalignantCD117-expressinghematopoieticcells , Leukemia (2020) DOI: 10.1038 / s41375-020-0818-9