 Home > Active Ingredient News > Blood System > Leuk Res: the main clinical response to the treatment of patients with cutaneous leukemia with bromine domain inhibitors PLX51107 and azacytidine

Leuk Res: the main clinical response to the treatment of patients with cutaneous leukemia with bromine domain inhibitors PLX51107 and azacytidine

 Last Update: 2022-09-20
 Source: Internet
 Author: User

Tags

dragon skin silicone

function plasma

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

PLX51107 is a highly effective oral bromine domain inhibitor with moderate selectivity for BD1, the first N-terminal bromine domain of bet family proteins

A 70-year-old woman with a 3-year history of isolated mononucleosis was diagnosed with cutaneous leukemia

When the authors visited their facility, there were many purple 2-5 cm tumors and plaques on the trunk and limbs (Figure 1a

Figure 1: a.

Figure 2: a.

BM biopsy is negative for AML involvement

Patients received the BET inhibitor PLX51107 120 mg PO daily on days 1 to 21 and AZA 75 mg/^m2 IV every

Overall, the response of patients to the treatment of skin diseases with PLX51107/AZA was an improvement in clinical response and overall well

In this case, a significant response to bet inhibitors in combination with AZA highlights the possibility of improving skin-associated leukemia activity

A Phase 2 clinical trial evaluating PLX51107 and AZA in AML and MDS is currently underway (NCT04022785

Original source:

Kim K, Bazinet A, Loghavi S, Konopleva M, Bhalla K, Daver N, Khoury JD, Kadia T, Wilson NR, Curry JL, Heberton M, Miller D, Pierce S, Borthakur G, Pemmaraju N.

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

SULODEXIDE 99% Almost White Powder Dideu-01112 Dideu

CAS No.: 57821-29-1

Pharmacy Grade

$61.76/G EXW

Heparin sodium 9041-08-1 vials safe delivery

CAS No.: 9041-08-1

Pharmacy Grade

$1/G EXW

Gadusol Powder Gadusol76663-30-4

CAS No.: 76663-30-4

Industrial Grade

$1-1.01/G FOB

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.