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Lancet Rheumatology: SARS-CoV-2 seropositivity in patients with autoimmune disease is even better for new crown vaccine

 Last Update: 2022-03-03
 Source: Internet
 Author: User

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Vaccines have played an important role as a public health intervention during the COVID-19 pandemic

In The Lancet Rheumatology,Nadia E Aikawa and colleagues report a subgroup analysis of the CoronavRheum study comparing SARS-CoV-2 seropositive or seronegative autoimmune rheumatic patients with seropositive or seronegative CoronaVac Immunogenicity of Negative Control

In The Lancet Rheumatology, 942 participants were included in the subgroup analysis, including 157 seropositive patients, 157 seropositive controls, 471 seronegative patients with autoimmune rheumatism, 157 seropositive patients Negative control (

All participants received two doses of CoronaVac on days 0 and 28

All participants received two doses of CoronaVac on days 0 and 28 vs vs vs.

In autoimmune rheumatic patients exposed to natural SARS-CoV-2 infection, a single dose of CoronaVac may be sufficient to generate a strong antibody response, whereas unexposed individuals require at least two doses

One study showed that immunocompromised individuals generally had weaker antiviral immune responses and vaccine responsiveness than healthy controls

Source: Xing-Su Gao, Feng-Cai Zhu, Distinct immune response to CoronaVac in SARS-CoV-2 seropositive and seronegative patients with autoimmune rheumatic disease, The Lancet Rheumatology, Volume 4, Issue 2,2022,Pages e77-e78,

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