Lancet respir med: Reducing sedatives of benzodiazepines and increased visitation can reduce the risk of delirium in patients with severe neo-coronary pneumonia

Mechanical breathing is a common method for treating patients with severe neo-coronary pneumonia.
so far, 750,000 Covid-19 patients worldwide need mechanical aeration, which studies have shown can lead to an increased risk of acute brain dysfunction (coma and delirium).
researchers recently studied delirium and coma rates and associated risk factors in patients with Covid-19 critical conditions.
This multi-center study was conducted in 69 adult ICU centers in 14 countries, involving patients over 18 years of age who received ICU care for severe neocyctic pneumonia, and collected demographic, delirium and coma assessments of patients and 21-day treatment data from electronic medical records, focusing on ventilator support, ICU treatment time and life status data.
the study was the prevalence of delirium and coma, as well as any associated risk factors associated with increased delirium.
2088 patients with severe neo-coronary pneumonia treated with ICU participated in the study, with an average age of 64 years, with an average SAPS II score of 40.0,1397 (66.9%) who had a mechanical agency on the day of ICU admission, and 1827 (87.5%) who had a mechanical angness during their hospitalization.
When mechanically breathed, most patients received sedatives, and of the 2088 patients, 1,337 (64.0%) were given benzodiazepines, with an average use of 7.0 days, 1481 cases (70.9%) giving propofol, an average of 7.0 days, and an average RASS sedative score of -4.
1704 (81.6%) had a coma for 10 days and 1,147 (54.9%) had an average delirium time of 3.0 days.
The acceptance of mechanical aeration, bondage, benzodiazepine drug use, the use of opioids, angiostamines, and antipsychotic drugs increases the risk of delirium in patients, while family visits (in person or video visits) reduce the risk of delirium.
, the average time for patients to survive without delirium or coma was 5.0 days.
age, high SAPS II score, male, smoking, alcoholism, 1st day in hospital use of booster was associated with no delirium, no coma survival time shortened.
28 hospitalizations, 601 (28.8%) of the 2,088 patients died, with the highest mortality rate during ICU treatment.
study found that patients with severe neo-coronary pneumonia had a higher risk of acute cerebral dysfunction, and that sedation with benzodiazepines and lack of family visits were variable risk factors for delirium.