Lancet Psychiatry |。 One million people found that statin use was not associated with suicide, anxiety or seizures

Statins are one of the most widely prescribed drugs in the world because of their anti-thrombosis, anti-inflammatory and antioxidant effects and have been widely studied and recommended for first- and second-level prevention of cardiovascular events.
, however, the potential neuropsychiasteric side effects of statins have been a cause for concern, including increased anxiety, depression and suicidal tendencies.
these concerns are based primarily on case series and some observational studies.
, case-control studies and randomized controlled trials showed no such association.
there is evidence that statins are beneficial for depression as an additional treatment for SSRIs.
addition, the use of statins alone (i.e., not assisted SSRI treatment) may have protective effects on depression, psychiatric hospitalization, and suicidal behavior, but the results are inconsistent.
statins may also reduce the risk of seizures, but other studies have shown no such effect.
yasmina Molero et al., of oxford University, used data from the Swedish National Registry to include people who took statins between 1 January 2006 and 31 December 2013 and were over 15 years of age, and linked data from statin prescriptions to data from specialist outpatients to produce four neuropsychiatric outcomes: suicidal behaviour (including suicide deaths), depression, anxiety and seizures.
results showed that the queue of statin users included 1149,384, of whom 1015,949 (884%) were over 50 years old, 625,616 (544%) were men and 523,768 (456%) were women.
the study period, 2053310 did not receive statin therapy and 2997545 received statin therapy, and 957216 (83.3%) individuals had changes in the status of useful drugs (from statins to non-statins and vice versa).
statin treatment, 6,372 (0.6%) committed suicide, 23,745 (21%) showed depression, 30,100 (26%) showed anxiety, and 28,844 (25%) had seizures.
the treatment cycle of statins was not significantly associated with suicidal behavior or suicide death (HR=0.99, 95% CI 0.90-1.08), nor was it related to anxiety or seizures.
statins were associated with a reduced risk of depressive disorder (HR-0.91,95% CI 0.87-0.94), and persisted after taking antidepressants at the same time.
significance of this study is that the use of statins is not associated with suicide, anxiety or seizures.
although a link was found between statin use and a decrease in clinical depression diagnosis, the observed link was whether it was related to the use of other drugs and needed further exploration.
Molero, Y., Cipriani, A., Larsson, H., Lichtenstein, P., D'Onofrio, B.M., samp; Fazel, S. (2020). Associations between statin use and suicidality, depression, anxiety, and seizures: a Swedish total-population cohort study. The Lancet Psychiatry, 7(11), 982-990.<!--5f39ae17-8c62-4a45-bc43-b32064c9388a: W3siYmxvY2tJZCI6IjU5NTQtMTYwOTEwNDIwMDU3NCIsImJsb2NrVHlwZSI6InBhcmFncmFwaCIsInN0eWxlcyI6eyJhbGlnbiI6ImxlZnQiLCJpbmRlbnQiOjAsInRleHQtaW5kZW50IjowLCJsaW5lLWhlaWdodCI6MS43NSwiYmFjay1jb2xvciI6IiIsInBhZGRpbmciOiIifSwidHlwZSI6InBhcmFncmFwaCIsInJpY2hUZXh0Ijp7ImRhdGEiOlt7ImNoYXIiOiJMIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6ImEiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoibiIsInN0eWxlcyI6e。 yJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJjIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6ImUiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoidCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiIgIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IlAiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoicyIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYX。 IiOiJ5Iiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6ImMiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiaCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJpIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6ImEiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoidCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiJyIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiI。 jZmZmZmZmIn19LHsiY2hhciI6InkiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiLSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiIxIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IjAiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoiMCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLkuIciLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5Lq6Iiwic3R5。 bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IueahCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLnoJQiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi56m2Iiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IuWPkSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLnjrAiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi77yMIiwic3R5bGVzIjp7ImJhY2stY29sb3IiO。 iIjZmZmZmZmIn19LHsiY2hhciI6IuS7liIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLmsYAiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi6I2vIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IueJqSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLkvb8iLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi55SoIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhci。 I6IuS4jiIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLoh6oiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5p2AIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IuOAgSIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLnhKYiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi6JmRIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IueXhyIsInN0eWxlcyI6eyJ。 iYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLmiJYiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi55mrIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IueXqyIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZmZiJ9fSx7ImNoYXIiOiLlj5EiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX0seyJjaGFyIjoi5L2cIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIjZmZmZmZmIn19LHsiY2hhciI6IuaXoCIsInN0eWxlcyI6eyJiYWNrLWNvbG9yIjoiI2ZmZmZm。 ZiJ9fSx7ImNoYXIiOiLlhbMiLCJzdHlsZXMiOnsiYmFjay1jb2xvciI6IiNmZmZmZmYifX1dLCJpc1JpY2hUZXh0Ijp0cnVlLCJrZWVwTGluZUJyZWFrIjp0cnVlfX0seyJibG9ja0lkIjoiNDQ5Ny0xNjA5MTA1NDIzMzU3IiwiYmxvY2tUeXBlIjoicGFyYWdyYXBoIiwic3R5bGVzIjp7ImJhY2stY29sb3IiOiIiLCJh。