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Lancet Oncology: Radiotherapy and chemotherapy for locally advanced head and neck tumors: a meta-analysis of individual patient data

 Last Update: 2021-05-31
 Source: Internet
 Author: User

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Progress in the treatment of locally advanced head and neck tumors has increased the cure rate.

A meta-analysis of individual patient data for head and neck cancer chemotherapy (MACH-NC) showed that combined chemotherapy on the basis of radiotherapy can improve overall survival, progression-free survival and local control rates, and reduce cancer deaths.

In this article, we conducted a frequency network meta-analysis based on meta-analysis data of individual patients.

Figure 1: Network diagram of overall survival rate trials

The 115 randomized controlled trials that included patients from January 1, 1980 to April 30, 2012 yielded 154 comparative results (19,253 deaths out of 28,978 patients, and 20579 progressive events).

And the CLRT _P compared, better overall survival P values of the other three treatments, no HR but significant improvement (P = 78%): taxanes, cisplatin and fluorouracil induction chemotherapy followed by topical treatment (the IC _TaxPF - LRT; 89%), accelerated concurrent chemoradiation (82%) and _CLRT after IC TaxPF (80%).

_P_TaxPF_TaxPF

In summary, this network meta-analysis allows evaluation of multiple treatment modalities and shows that HFCRT is superior to other treatments.

HFCRT is better than other treatments.

Petit, ClaireAdelstein, DJ et al.
Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis.
The Lancet Oncology, Volume 22, Issue 5, 727-736 Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis.

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