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Lancet Oncol: The effect of long-term maintenance treatment with olaparib on the quality of life of patients

 Last Update: 2021-05-08
 Source: Internet
 Author: User

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In the Phase 3 SOLO1 trial, olaparib maintenance treatment provided newly diagnosed BRCA mutations in patients with advanced ovarian cancer who had remission after platinum-based chemotherapy and provided significantly longer progression-free survival than the placebo group.

Ovarian cancer

This article analyzes the health-related quality of life (HRQOL) and patient-centered prognostic results of patients in the SOLO1 trial, as well as the impact of radiation disease progression on health.

The SOLO1 trial is a randomized, double-blind phase 3 trial conducted in 118 centers in 15 countries.

From September 3, 2013 to March 6, 2015, a total of 1084 patients were recruited, of which 693 met the requirements.

PFS of the two groups and PFS adjusted for quality of life

The median follow-up time for the olaparib group and the placebo group were 40.

The quality of life adjusted progression-free survival (mean: 29.

For patients with cancer types evaluated in this trial, olaparib maintenance therapy not only provides excellent progression-free survival benefits, but also does not reduce the patient’s quality of life.

Original source:

Michael Friedlander, et al.

Atezolizumab, Bevacizumab, and Chemotherapy for Newly Diagnosed Stage III or IV Ovarian Cancer: Placebo-Controlled Randomized Phase III Trial (IMagyn050 / GOG 3015 / ENGOT-OV39) in this message

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