Lancet Neurology: 1 case of SARS-CoV-2 infection suspected to cause Parkinson's disease

Parkinson's disease or Parkinson's disease is often described after a viral infection, such as influenza A virus, Epstein-Barr virus, chickenpox shingles virus, hepatitis C virus, HIV, Japanese encephalitis virus or West Nile virus.
report in this article that a patient may have Parkinson's disease who was diagnosed with Severe Acute Respiratory Syndrome Coronary Virus 2 (SARS-CoV-2).
17, 2020, a 45-year-old Jew was hospitalized in Assuta Ashdod University Hospital in Samson Assuta Ashdod, Israel, with dry cough and muscle pain.
days before he was admitted to hospital, he also noticed a loss of his sense of smell.
began on March 11, two days after returning to Israel from a week-long trip to the United States.
he may have been exposed to the virus on a flight back to Israel because he recalled a passenger sitting behind him coughing repeatedly.
his previous medical history included high blood pressure, taking 200 milligrams of la bellool, 80 milligrams of prostamol and 5 milligrams of ammonia chloride daily.
, he also suffers from asthma.
nasopharyngeal swab on the day of his hospitalization, he was found to be positive for SARS-CoV-2, with a full blood count and cRP testing normal, via real-time RT-PCR testing.
patients experienced fatigue, shortness of breath and chest pain, but no fever, during their stay in ward 19 of COVID.
he received three days of treatment as an inpatient, mainly using saldamine inhalants for mild asthma symptoms, without the need for systemic medication, oxygen supplementation or mechanical aeration.
the patient was subsequently quarantined on 20 March.
, he had nasopharyngeal swabs on 25 March and 30 March, which turned out to be negative.
, however, during the three-week quarantine period, he noticed that his handwriting had changed, becoming smaller and less readable than before.
it was difficult for him to start texting on his phone.
his right hand also had a tremor.
he returned home, he continued to develop these symptoms and was eventually taken to the neurology department.
During the examination, the patient experienced language disorders, moderate stiffness in the neck and right arm, mild stiffness in the left arm, moderate movement in the right limb, mild movement in the left limb, and no tremors.
his gait was slightly slower, he didn't swing his right arm, and his elbows were cranky when he walked, but his slew and height were normal.
was not found in the pull test.
computerized fault scans of the brain, dispersion on magnetic resonance imaging and fluid attenuation reversal recovery sequences, and electro-encephalograms were normal.
but PET scans showed a decrease in 18F-FDOPA intake in both nuclei, with a more pronounced left side.
, Parkinson's disease is often associated with a lack of sense of smell, a common feature of SARS-CoV-2 infections.
activation of the olfactory system may eventually lead to α folding of the Synaptic nucleoprotein and the progression of Parkinson's disease.
this mechanism was supported by autopsy studies that showed elevated levels of TNF, IL1 and IL6.
, Parkinson's patients responded more to PSG antibodies to seasonal coronavirus than in age-matching health control groups.
Cohen, Mikhal E et al. A case of probable Parkinson's disease after SARS-CoV-2 infect. The Lancet Neurology, Volume 19, Issue 10, 804 - 805MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medical and are not authorized to be reproduced by any media, website or individual.
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