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LANCET HEALTHY LONGEVITY: Is the brain healthy, look at the brain-PAD indicator

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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Aging is associated with significant inter-individual effects on function, morbidity, and mortality

Brain age is an examination of biological aging from a neuroanatomical perspective

Many studies examining variability in the biology of aging are limited by participant chronological age variability, reliance on retrospective data collection, and heterogeneity in image acquisition and processing

Brain age is a neuroimaging-based biomarker thought to reflect changes during brain aging and predict longevity

The Lancet journal LANCET HEALTHY LONGEVITY recently published a study by Aaron Z Wagen et al.

The study applied a well-established model of brain age to obtain brain-PAD from structural imaging of Insight 46 participants

A total of 456 patients (225 women) were included in the study, with a mean age of 70.

Brain predicted age compared to actual age and gender

Hierarchical division of significant variables showing the independent contribution of each metric to the variance explained in brain-PAD

The relationship between brain-PAD and brain atrophy rate in subsequent 2 years

Brain-PAD is associated with cardiovascular risk, imaging and biochemical markers of neurodegeneration

original source

Life course, genetics, and neuropathological associations with brain age in the 1946 British Birth Cohort: a population-based study

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