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Lancet Haematol: Clinically true data of Tisagenlecleucel in young children and infants with acute lymphoblastic leukemia

 Last Update: 2022-09-20
 Source: Internet
 Author: User

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In the phase 2 ELIANA trial on Tisagenlecleucel for the treatment of children with acute lymphoblastic leukemia, children

The study aimed to analyze real-world data on the feasibility, activity and safety of Tisagenlecleucel in young children and infants with acute lymphoblastic

This is an international, multicenter, retrospective cohort study of children

Of the 38 eligible children screened, 35 (92 percent) received a Tisagenlecleucel infusion

After a median follow-up of 14 months, the overall survival rate at 12 months after Tisagenlecleucel infusion was 84%, the event-free survival rate was 69%, and the strict event-free survival rate was 41%.

Adverse reactions included cytokine release syndrome, seen in 21 (60%) children (of any grade), 5 children developed cytokine release syndrome of grade 3-4; Nine children experienced neurotoxicity (of any level) and none was severe

Taken together, these data suggest that Tisagenlecleucel has good antitumor activity and acceptable safety

Original source:

Sara Ghorashian, et al.

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